Journal article
Comparison of the occurrence of positive and negative vascular remodeling in patients with stable vs unstable angina pectoris
Vnitřní lékar̆stvĭ, Vol.49(2), pp.103-108
02/01/2003
PMID: 12728576
Abstract
BACKGROUNDThe vascular remodelling refers to the increase or decrease in EEM (external elastica membrane) area that occurs during development of atherosclerosis. The positive remodeling, which was thought only as a compensatory factor during atheroma development, was also found as a one of the main features of unstable plaque. The intravascular ultrasound is very good tool to measure different type of arterial remodelling. These findings correlate with histologic post-mortem specimen with excellent results.AIM OF THE STUDYTo correlate the remodelling index from patients suffered from stable angina pectoris (SAP) and from patients suffered from unstable angina (UA).METHODWe performed IVUS in 51 patients. In the group of patients with unstable angina were included patients with worsening angina symptoms in last six weeks or with angina in rest. We used IVUS--endosonics In-Vision with 30 MHz probe Awanar with mechanical pull-back. We studied the occurrence of positive remodelling, negative remodeling (an index that describes remodeling is expressed as: lesion EEM CSA/reference EEM CSA. If the lesion EEM area is greater than the reference EEM area, positive remodelling has occurred, and the index will be > 1.0. If the lesion EEM area is smaller than the reference EEM area, negative remodelling has occurred, and the index will be < 1.0).RESULTSWe performed the intravascular ultrasound in 51 patients, 22 patients (43.1%) with unstable angina (UA) and in 29 patients (56.9%) stable angina (SAP). The positive remodelling was found in 14 patients (63.6%) in UA group vs. 5 patients (17.2%) in group with SAP, p < 0.05. The negative remodelling was found in 6 patients (27.3%) in UA group vs. 23 patients (79.3%) in SAP group, p < 0.05.CONCLUSIONPositive remodelling is more often found in patients with UA vs. in patients with SAP. Positive arterial remodelling is therefore one of the features of unstable atherosclerotic plaque.
Details
- Title: Subtitle
- Comparison of the occurrence of positive and negative vascular remodeling in patients with stable vs unstable angina pectoris
- Creators
- T KovárníkV ReznícekK NováckováA LinhartJ BĕlohlávekF HolmJ HorákM Aschermann
- Resource Type
- Journal article
- Publication Details
- Vnitřní lékar̆stvĭ, Vol.49(2), pp.103-108
- PMID
- 12728576
- ISSN
- 0042-773X
- Language
- Czech
- Date published
- 02/01/2003
- Academic Unit
- Electrical and Computer Engineering
- Record Identifier
- 9984627251202771
Metrics
4 Record Views