Comparison of versions 1.0 AND 1.5 of the UltraSensitive AMPLICOR HIV-1 MONITOR test for subjects with low viral load

J Brooks Jackson; Estelle Piwowar-Manning; LeTanya Johnson-Lewis; Roland Bassett; Lisa M Demeter; Donald Brambilla

doi:10.1128/JCM.42.6.2774-2776.2004

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Comparison of versions 1.0 AND 1.5 of the UltraSensitive AMPLICOR HIV-1 MONITOR test for subjects with low viral load

Journal article

Open access

Peer reviewed

Comparison of versions 1.0 AND 1.5 of the UltraSensitive AMPLICOR HIV-1 MONITOR test for subjects with low viral load

J Brooks Jackson, Estelle Piwowar-Manning, LeTanya Johnson-Lewis, Roland Bassett, Lisa M Demeter and Donald Brambilla

Journal of clinical microbiology, Vol.42(6), pp.2774-2776

06/2004

DOI: 10.1128/JCM.42.6.2774-2776.2004

PMCID: PMC427852

PMID: 15184467

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Abstract

We compared the performance of two UltraSensitive AMPLICOR HIV-1 MONITOR kits (version 1.5 [v1.5] versus v1.0) by retesting 404 plasma samples with low viral loads (<3,000 copies/ml) with both kits. With 292 samples that initially had <50 copies/ml by the v1.0 kit, the v1.5 assay was more sensitive than the v1.0 assay for samples with human immunodeficiency virus type 1 RNA near the 50-copy/ml cutoff (P = 0.0146). Median numbers of copies per milliliter were similar for 112 samples with 50 to 3,000 copies/ml with no difference in sensitivity with a 200-copy/ml cutoff.

HIV-1 - isolation & purification

Humans

Reagent Kits, Diagnostic

Sensitivity and Specificity

RNA, Viral - analysis

HIV-1 - genetics

Viral Load

Details

Title: Subtitle: Comparison of versions 1.0 AND 1.5 of the UltraSensitive AMPLICOR HIV-1 MONITOR test for subjects with low viral load
Creators: J Brooks Jackson - Johns Hopkins Medical Institutions, Carnegie Building, Room 415, 600 North Wolfe St., Baltimore, MD 21287, USA. bjackso@jhmi.edu
Estelle Piwowar-Manning
LeTanya Johnson-Lewis
Roland Bassett
Lisa M Demeter
Donald Brambilla
Resource Type: Journal article
Publication Details: Journal of clinical microbiology, Vol.42(6), pp.2774-2776
DOI: 10.1128/JCM.42.6.2774-2776.2004
PMID: 15184467
PMCID: PMC427852
NLM abbreviation: J Clin Microbiol
ISSN: 0095-1137
eISSN: 1098-660X
Publisher: United States
Language: English
Date published: 06/2004
Academic Unit: Pathology; VPMA - Administration
Record Identifier: 9984046833002771

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