Journal article
Comparison of β-blockers, amiodarone plus β-blockers, or sotalol for prevention of shocks from implantable cardioverter defibrillators : The optic study: A randomized trial
JAMA : the journal of the American Medical Association, Vol.295(2), pp.165-171
2006
DOI: 10.1001/jama.295.2.165
PMID: 16403928
Abstract
Context: Implantable cardioverter defibrillator (ICD) therapy is effective but is associated with high-voltage shocks that are painful. Objective: To determine whether amiodarone plus β-blocker or sotalol are better than β-blocker alone for prevention of ICD shocks. Design, Setting, and Patients: A randomized controlled trial with blinded adjudication of events of 412 patients from 39 outpatient ICD clinical centers located in Canada, Germany, United States, England, Sweden, and Austria, conducted from January 13, 2001, to September 28, 2004. Patients were eligible if they had received an ICD within 21 days for inducible or spontaneously occurring ventricular tachycardia or fibrillation. Intervention: Patients were randomized to treatment for 1 year with amiodarone plus β-blocker, sotalol alone, or β-blocker alone. Main Outcome Measure: Primary outcome was ICD shock for any reason. Results: Shocks occurred in 41 patients (38.5%) assigned to β-blocker alone, 26 (24.3%) assigned to sotalol, and 12 (10.3%) assigned to amiodarone plus β-blocker. A reduction in the risk of shock was observed with use of either amiodarone plus β-blocker or sotalol vs β-blocker alone (hazard ratio [HR], 0.44; 95% confidence interval [CI], 0.28-0.68; P<.001). Amiodarone plus β-blocker significantly reduced the risk of shock compared with β-blocker alone (HR, 0.27; 95% CI, 0.14-0.52; P<.001) and sotalol (HR, 0.43; 95% CI, 0.22-0.85; P=.02). There was a trend for sotalol to reduce shocks compared with β-blocker alone (HR, 0.61; 95% CI, 0.37-1.01; P=.055). The rates of study drug discontinuation at 1 year were 18.2% for amiodarone, 23.5% for sotalol, and 5.3% for β-blocker alone. Adverse pulmonary and thyroid events and symptomatic bradycardia were more common among patients randomized to amiodarone. Conclusions: Despite use of advanced ICD technology and treatment with a β-blocker, shocks occur commonly in the first year after ICD implant. Amiodarone plus β-blocker is effective for preventing these shocks and is more effective than sotalol but has an increased risk of drug-related adverse effects. Clinical Trials Registration: ClinicalTrials.gov Identifier: NCT00257959. ©2006 American Medical Association. All rights reserved.
Details
- Title: Subtitle
- Comparison of β-blockers, amiodarone plus β-blockers, or sotalol for prevention of shocks from implantable cardioverter defibrillators : The optic study: A randomized trial
- Creators
- Stuart J Connolly - McMaster UniversityPaul Dorian - University of TorontoGerian C Gronefeld - Goethe University FrankfurtStefan H Hohnloser - Goethe University FrankfurtRobin S Roberts - McMaster UniversityMichael Gent - McMaster UniversitySteven Bailin - Iowa Heart center, Des Moines, United StatesEric S Fain - St Jude Medical, cardiac Rhythm Management Division, Sylmar, Calif, United StatesKevin Thorpe - McMaster UniversityJean Champagne - Department of Medicine, University of Laval, Quebec, CanadaMario Talajic - Université de MontréalBenoit Coutu - Université de MontréalOPTIC Investigators
- Resource Type
- Journal article
- Publication Details
- JAMA : the journal of the American Medical Association, Vol.295(2), pp.165-171
- DOI
- 10.1001/jama.295.2.165
- PMID
- 16403928
- NLM abbreviation
- JAMA
- ISSN
- 0098-7484
- eISSN
- 1538-3598
- Publisher
- American Medical Association
- Language
- English
- Date published
- 2006
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984360042602771
Metrics
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