Journal article
Comparisons of different sampling designs for the determination of genetic transmission mechanisms in quantitative traits
American journal of human genetics, Vol.36(5), pp.1060-1074
1984
PMCID: PMC1684505
PMID: 6496473
Abstract
The power provided by several sampling designs to detect segregation at a major locus was investigated in a simulation study using phenotypes constructed from a major-locus genotypic mean, a background polygenic effect, and an individual-specific environmental effect. Questions of which relatives, how many relatives, and how many independent pedigrees to collect were considered, using configurations ranging from nuclear families of size 5 to 4-generation pedigrees of size 45. Each configuration contained a single proband whose phenotype exceeded the 95th percentile in a population where 2.5% carry the disease susceptibility allele. Results suggest that, under the conditions simulated, when total sample size is fixed, samples composed of 3-generation pedigrees of intermediate size provide a greater magnitude of support for the presence of a major locus than do samples composed of nuclear families or 4-generation pedigrees. This study is the first to consider both the discriminatory power and estimation efficiency in comparing alternative sampling strategies for pedigree data.
Details
- Title: Subtitle
- Comparisons of different sampling designs for the determination of genetic transmission mechanisms in quantitative traits
- Creators
- T. L Burns - University of IowaP. P Moll - University of IowaM. A Schork - University of Iowa
- Resource Type
- Journal article
- Publication Details
- American journal of human genetics, Vol.36(5), pp.1060-1074
- Publisher
- University of Chicago Press
- PMID
- 6496473
- PMCID
- PMC1684505
- ISSN
- 0002-9297
- eISSN
- 1537-6605
- Language
- English
- Date published
- 1984
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984364426502771
Metrics
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