Journal article
Compensatory Hyperconnectivity in Developing Brains of Young Children With Type 1 Diabetes
Diabetes (New York, N.Y.), Vol.66(3), pp.754-762
03/2017
DOI: 10.2337/db16-0414
PMCID: PMC5319714
PMID: 27702833
Abstract
Sustained dysregulation of blood glucose (hyper- or hypoglycemia) associated with type 1 diabetes (T1D) has been linked to cognitive deficits and altered brain anatomy and connectivity. However, a significant gap remains with respect to how T1D affects spontaneous at-rest connectivity in young developing brains. Here, using a large multisite study, resting-state functional MRI data were examined in young children with T1D (
= 57; mean age = 7.88 years; 27 females) as compared with age-matched control subjects without diabetes (
= 26; mean age = 7.43 years; 14 females). Using both model-driven seed-based analysis and model-free independent component analysis and controlling for age, data acquisition site, and sex, converging results were obtained, suggesting increased connectivity in young children with T1D as compared with control subjects without diabetes. Further, increased connectivity in children with T1D was observed to be positively associated with cognitive functioning. The observed positive association of connectivity with cognitive functioning in T1D, without overall group differences in cognitive function, suggests a putative compensatory role of hyperintrinsic connectivity in the brain in children with this condition. Altogether, our study attempts to fill a critical gap in knowledge regarding how dysglycemia in T1D might affect the brain's intrinsic connectivity at very young ages.
Details
- Title: Subtitle
- Compensatory Hyperconnectivity in Developing Brains of Young Children With Type 1 Diabetes
- Creators
- Manish Saggar - Center for Interdisciplinary Brain Sciences Research, Stanford University School of Medicine, Stanford, CA saggar@stanford.eduEva Tsalikian - Division of Endocrinology and Diabetes, Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IANelly Mauras - Pediatric Endocrinology, Nemours Children's Health System, Jacksonville, FLPaul Mazaika - Center for Interdisciplinary Brain Sciences Research, Stanford University School of Medicine, Stanford, CANeil H White - Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MOStuart Weinzimer - Department of Pediatrics, Yale University School of Medicine, New Haven, CTBruce Buckingham - Division of Endocrinology and Diabetes, Department of Pediatrics, Stanford University School of Medicine, Stanford, CATamara Hershey - Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MOAllan L Reiss - Center for Interdisciplinary Brain Sciences Research, Stanford University School of Medicine, Stanford, CADiabetes Research in Children Network (DirecNet)
- Resource Type
- Journal article
- Publication Details
- Diabetes (New York, N.Y.), Vol.66(3), pp.754-762
- DOI
- 10.2337/db16-0414
- PMID
- 27702833
- PMCID
- PMC5319714
- ISSN
- 0012-1797
- eISSN
- 1939-327X
- Grant note
- U10 HD041915 / NICHD NIH HHS R01 HD078463 / NICHD NIH HHS U10 HD041908 / NICHD NIH HHS U10 HD041906 / NICHD NIH HHS K99 MH104605 / NIMH NIH HHS U10 HD056526 / NICHD NIH HHS P30 DK045735 / NIDDK NIH HHS U10 HD041918 / NICHD NIH HHS
- Language
- English
- Date published
- 03/2017
- Academic Unit
- Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984093234102771
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