Journal article
Complement-Enhanced Neutralizing Antibody Response to Varicella-Zoster Virus
The Journal of infectious diseases, Vol.139(4), pp.432-437
04/1979
DOI: 10.1093/infdis/139.4.432
PMID: 220336
Abstract
Humoral immunity following infection with varicella-zoster virus (VZV) was evaluated by a complement-enhanced neutralization test. The specificity of the test was examined and its sensitivity compared with that of the assay which measures antibody to VZV-induced membrane antigen (FAMA). Generally, the titer of neutralizing antibody was two- to fourfold higher than the FAMA titer. The absence of neutralizing activity at a serum dilution of 1:4 indicated susceptibility of the donor to VZV infection and correlated with an absence of FAMA (titer, <1:2). A survey of susceptible leukemic children exposed to chicken pox revealed that several recipients of zoster immune globulin had a subclinical infection, as manifested by seroconversion and persistence of neutralizing antibody to VZV. Results of these studies indicate that the complement-enhanced neutralization test is a sensitive and specific assay for determination of humoral immune status with regard to VZV in healthy and immunosuppressed individuals.
Details
- Title: Subtitle
- Complement-Enhanced Neutralizing Antibody Response to Varicella-Zoster Virus
- Creators
- Charles Grose - From the Virology Laboratory, Department of Pediatrics, University of Texas Health Science Center, San Antonio, TexasBetty J Edmond - From the Virology Laboratory, Department of Pediatrics, University of Texas Health Science Center, San Antonio, TexasPhilip A Brunell - From the Virology Laboratory, Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.139(4), pp.432-437
- Publisher
- The University of Chicago Press
- DOI
- 10.1093/infdis/139.4.432
- PMID
- 220336
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Language
- English
- Date published
- 04/1979
- Academic Unit
- Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984093481702771
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