Complement activation and choriocapillaris loss in early AMD: Implications for pathophysiology and therapy

S. Scott Whitmore; Elliott H Sohn; Kathleen R Chirco; Arlene V Drack; Edwin M Stone; Budd A Tucker; Robert F Mullins

doi:10.1016/j.preteyeres.2014.11.005

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Complement activation and choriocapillaris loss in early AMD: Implications for pathophysiology and therapy

Journal article

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Complement activation and choriocapillaris loss in early AMD: Implications for pathophysiology and therapy

S. Scott Whitmore, Elliott H Sohn, Kathleen R Chirco, Arlene V Drack, Edwin M Stone, Budd A Tucker and Robert F Mullins

Progress in Retinal and Eye Research, Vol.45, pp.1-29

03/2015

DOI: 10.1016/j.preteyeres.2014.11.005

PMCID: PMC4339497

PMID: 25486088

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http://doi.org/10.1016/j.preteyeres.2014.11.005View

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Abstract

Age-related macular degeneration (AMD) is a common and devastating disease that can result in severe visual dysfunction. Over the last decade, great progress has been made in identifying genetic variants that contribute to AMD, many of which lie in genes involved in the complement cascade. In this review we discuss the significance of complement activation in AMD, particularly with respect to the formation of the membrane attack complex in the aging choriocapillaris. We review the clinical, histological and biochemical data that indicate that vascular loss in the choroid occurs very early in the pathogenesis of AMD, and discuss the potential impact of vascular dropout on the retinal pigment epithelium, Bruch's membrane and the photoreceptor cells. Finally, we present a hypothesis for the pathogenesis of early AMD and consider the implications of this model on the development of new therapies.

Complement system

Choriocapillaris

Pathophysiology

Age-related macular degeneration

Choroidmacula

Endothelial cells

Details

Title: Subtitle: Complement activation and choriocapillaris loss in early AMD: Implications for pathophysiology and therapy
Creators: S. Scott Whitmore - The Stephen A. Wynn Institute for Vision Research, The University of Iowa, United States
Elliott H Sohn - The Stephen A. Wynn Institute for Vision Research, The University of Iowa, United States
Kathleen R Chirco - The Stephen A. Wynn Institute for Vision Research, The University of Iowa, United States
Arlene V Drack - The Stephen A. Wynn Institute for Vision Research, The University of Iowa, United States
Edwin M Stone - The Stephen A. Wynn Institute for Vision Research, The University of Iowa, United States
Budd A Tucker - The Stephen A. Wynn Institute for Vision Research, The University of Iowa, United States
Robert F Mullins - The Stephen A. Wynn Institute for Vision Research, The University of Iowa, United States
Resource Type: Journal article
Publication Details: Progress in Retinal and Eye Research, Vol.45, pp.1-29
DOI: 10.1016/j.preteyeres.2014.11.005
PMID: 25486088
PMCID: PMC4339497
NLM abbreviation: Prog Retin Eye Res
ISSN: 1350-9462
eISSN: 1873-1635
Publisher: Elsevier Ltd
Grant note: DOI: 10.13039/100000053, name: National Eye Institute, award: EY-016822, EY-024605; DOI: 10.13039/100000002, name: National Institutes of Health, award: 1DP2OD007483; name: Elmer and Sylvia Sramek Charitable Foundation
Language: English
Date published: 03/2015
Academic Unit: Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
Record Identifier: 9983979977202771

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