Complement activation at the interface between adipocytes and cancer cells drives tumor progression

This research was supported by funding from the US Department of Veterans Affairs (grant BX006012) , the Department of Defense (grant W81XWH-21-1-0378) , the Diana Princess of Wales endowed Professorship from the Lurie Cancer Center (to DM) , and an Ovarian Cancer Research Alliance postdoctoral fellowship (to AV) . Tumor specimens were procured through the Pathology Core and sequencing was performed in the NUSeq Core supported by National Cancer Institute (NCI) grant CCSG P30 CA060553 awarded to the Robert H. Lurie Comprehensive Cancer Center. Flow cytometry analyses were performed in the Northwestern University-Flow Cytometry Core Facility and histology services were provided by the Northwestern University Mouse Histol-ogy and Phenotyping Laboratory supported by NCI Cancer Center Support grant CA060553. Imaging was performed in the Center for Advanced Microscopy/Nikon Imaging Center (CAM) at Northwestern University supported by NCI grant CA060553. This research was supported in part through the computational resources and staff contributions provided for the Quest high-performance computing facility at Northwestern University, which is jointly supported by the Office of the Provost, the Office for Research, and Northwestern University Information Technology. The Functional Proteomics RPPA Core was supported in part by The University of Texas MD Anderson Cancer Center, which is supported by NIH grants P30CA016672 and R50CA221675. The graphical abstract was created in BioRender (https://BioRender.com /s53m632) .