Journal article
Complement, age-related macular degeneration and a vision of the future
Archives of ophthalmology (1960), Vol.128(3), pp.349-358
03/2010
DOI: 10.1001/archophthalmol.2010.18
PMCID: PMC4405117
PMID: 20212207
Abstract
Age-related macular degeneration (AMD) is one of the most well-characterized late-onset, complex trait diseases. Remarkable advances in our understanding of the genetic and biological foundations of this disease were derived from a recent convergence of scientific and clinical data. Importantly, the more recent identification of AMD-associated variations in a number of complement pathway genes has provided strong support for earlier, paradigm-shifting studies that suggested that aberrant function of the complement system plays a key role in disease etiology. Collectively, this wealth of information has provided an impetus for the development of powerful tools to accurately diagnose disease risk and progression and complement-based therapeutics that will ultimately delay or prevent AMD. Indeed, we are poised to witness a new era of a personalized approach toward the assessment, management, and treatment of this debilitating, chronic disease.
Details
- Title: Subtitle
- Complement, age-related macular degeneration and a vision of the future
- Creators
- Karen M Gehrs - Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, USAJared R JacksonEric N BrownRando AllikmetsGregory S Hageman
- Resource Type
- Journal article
- Publication Details
- Archives of ophthalmology (1960), Vol.128(3), pp.349-358
- DOI
- 10.1001/archophthalmol.2010.18
- PMID
- 20212207
- PMCID
- PMC4405117
- NLM abbreviation
- Arch Ophthalmol
- ISSN
- 0003-9950
- eISSN
- 1538-3601
- Publisher
- American Medical Association; United States
- Grant note
- R24 EY017404 / NEI NIH HHS R01 EY013435 / NEI NIH HHS R01 EY13435 / NEI NIH HHS
- Language
- English
- Date published
- 03/2010
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9983979910602771
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