Journal article
Complement and cellular cytotoxicity in antibody therapy of cancer
Expert opinion on biological therapy, Vol.8(6), pp.759-768
06/01/2008
DOI: 10.1517/14712598.8.6.759
PMID: 18476787
Abstract
The effective and practical use of mAbs in cancer therapy became a reality with the development of the chimeric anti-CD20 mAb, rituximab. Several additional mAbs have since been approved for clinical use. Despite these successes, the mechanisms by which mAbs mediate antitumor activity are still unclear. Preclinical studies indicate complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC) both can contribute to mAb-induced tumor cell lysis. However, evidence related to the relative clinical importance of each mechanism, and whether they are synergistic or antagonistic, is conflicting. New ways to enhance both CDC and ADCC are being developed in attempt to develop a more effective anticancer mAb. Continued research on the mechanisms of mAb therapy will be necessary if we are to take optimal advantage of the current mAbs and develop more effective mAbs in the future.
Details
- Title: Subtitle
- Complement and cellular cytotoxicity in antibody therapy of cancer
- Creators
- Siao-Yi Wang - University of IowaGeorge Weiner - Univ Iowa, Iowa City, IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- Expert opinion on biological therapy, Vol.8(6), pp.759-768
- Publisher
- Taylor & Francis
- DOI
- 10.1517/14712598.8.6.759
- PMID
- 18476787
- ISSN
- 1471-2598
- eISSN
- 1744-7682
- Number of pages
- 10
- Grant note
- T32GM007337 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Language
- English
- Date published
- 06/01/2008
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Pharmaceutical Sciences and Experimental Therapeutics; Internal Medicine
- Record Identifier
- 9984359697002771
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