Complete genomic sequence and phylogenetic relatedness of hepatitis B virus isolates in Cambodia

Tran Huy; Amadou Sall; Jean Reynes; Kenji Abe

doi:10.1007/s11262-008-0205-5

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Complete genomic sequence and phylogenetic relatedness of hepatitis B virus isolates in Cambodia

Journal article

Open access

Peer reviewed

Complete genomic sequence and phylogenetic relatedness of hepatitis B virus isolates in Cambodia

Tran Huy, Amadou Sall, Jean Reynes and Kenji Abe

Virus genes, Vol.36(2), pp.299-305

04/2008

DOI: 10.1007/s11262-008-0205-5

PMID: 18264750

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Abstract

Although it is known that Cambodia is one of the high endemic area of hepatitis B virus (HBV) infection, molecular characterization of HBV circulating in this country has not been reported. In this study, pre-S gene of HBV from 12 Cambodian patients was sequenced. Phylogenetic analysis based on the pre-S gene sequence revealed that 8 out of 12 isolates (66.7%) belonged to HBV/C1 and remaining four (33.3%) were HBV/B4. Furthermore, complete genomic sequences were also determined for three Cambodian HBV isolates. They all comprised of 3,215 bp long and two of them belonged to subgenotype B4, which had recombination event with genotype C in the precore/core gene confirmed by SimPlot and BootScanning analyses. Our results showed that both HBV strains belonged to subgenotypes B4 and C1, which are circulating in this country. This is the first report on molecular characterization of the HBV prevalent in Cambodia.

Medical Microbiology

Biomedicine

HBV genome

Cambodia

Hepatitis B virus (HBV)

HBV Asian strain

HBV genotypes

Plant Sciences

Virology

Details

Title: Subtitle: Complete genomic sequence and phylogenetic relatedness of hepatitis B virus isolates in Cambodia
Creators: Tran Huy - grid.410795.e 0000000122201880 Department of Pathology National Institute of Infectious Diseases Toyama 1-23-1, Shinjuku-ku Tokyo 162-8640 Japan
Amadou Sall - grid.418508.0 0000000119569596 Institut Pasteur de Dakar Dakar Senegal
Jean Reynes - grid.418511.8 0000000405527303 Institut Pasteur de Madagascar Antananarivo Madagascar
Kenji Abe - grid.410795.e 0000000122201880 Department of Pathology National Institute of Infectious Diseases Toyama 1-23-1, Shinjuku-ku Tokyo 162-8640 Japan
Resource Type: Journal article
Publication Details: Virus genes, Vol.36(2), pp.299-305
DOI: 10.1007/s11262-008-0205-5
PMID: 18264750
NLM abbreviation: Virus Genes
ISSN: 0920-8569
eISSN: 1572-994X
Publisher: Springer US
Language: English
Date published: 04/2008
Academic Unit: Gastroenterology and Hepatology; Internal Medicine
Record Identifier: 9984094575902771

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