Complete heart block in association with graft-versus-host disease

A. L GILMAN; N. W KOOY; D. L ATKINS; Z BALLAS; S RUMELHART; M HOLIDA; N LEE; F GOLDMAN

doi:10.1038/sj.bmt.1701038

Back

Complete heart block in association with graft-versus-host disease

Journal article

Peer reviewed

Complete heart block in association with graft-versus-host disease

A. L GILMAN, N. W KOOY, D. L ATKINS, Z BALLAS, S RUMELHART, M HOLIDA, N LEE and F GOLDMAN

Bone marrow transplantation (Basingstoke), Vol.21(1), pp.85-88

1998

DOI: 10.1038/sj.bmt.1701038

PMID: 9486500

View Online

Abstract

An infant who received haploidentical BM for severe combined immunodeficiency (SCID) developed acute, reversible complete heart block in association with an exacerbation of GVHD. Respiratory distress and myocardial dysfunction were also seen with this and previous GVHD exacerbations. The patient had not received chemotherapy or radiation prior to BMT. The complete heart block resolved after 1 week of intensive immunosuppression. The association of complete heart block with GVHD is important because the heart block is potentially reversible with prompt, aggressive control of the GVHD.

Biological and medical sciences

Medical sciences

Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy

Bone marrow, stem cells transplantation. Graft versus host reaction

Transfusions. Complications. Transfusion reactions. Cell and gene therapy

Details

Title: Subtitle: Complete heart block in association with graft-versus-host disease
Creators: A. L GILMAN - Division of Hematology/Oncology, Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA, United States
N. W KOOY - Division of Intensive Care, Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA, United States
D. L ATKINS - Division of Cardiology, Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA, United States
Z BALLAS - Department of Medicine, University of Iowa College of Medicine, Iowa City, IA, United States
S RUMELHART - Division of Hematology/Oncology, Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA, United States
M HOLIDA - Division of Hematology/Oncology, Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA, United States
N LEE - Division of Hematology/Oncology, Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA, United States
F GOLDMAN - Division of Hematology/Oncology, Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA, United States
Resource Type: Journal article
Publication Details: Bone marrow transplantation (Basingstoke), Vol.21(1), pp.85-88
DOI: 10.1038/sj.bmt.1701038
PMID: 9486500
NLM abbreviation: Bone Marrow Transplant
ISSN: 0268-3369
eISSN: 1476-5365
Publisher: Nature Publishing Group
Language: English
Date published: 1998
Academic Unit: Stead Family Department of Pediatrics; Immunology; Internal Medicine
Record Identifier: 9984094530102771

Metrics

18 Record Views

19 Times Cited - Web of Science

See more details