Journal article
Complex roles of PIP2 in the regulation of ion channels and transporters
American journal of physiology. Renal physiology, Vol.293(6), pp.F1761-1765
12/2007
DOI: 10.1152/ajprenal.00400.2007
PMID: 17928411
Abstract
The regulation of ion channels and transporters by phosphoinositides has received much attention over the past 10 years. There are multiple potential mechanisms for regulation of ion channels and transporters by PIP(2), including a direct binding of PIP(2) to the target proteins, alterations of membrane insertion, and retrieval. Added to the complexities of multiple potential mechanisms is how cells use PIP(2) to regulate so many different processes. Here, I briefly review several past and recent studies to illustrate the complexities and raise outstanding questions for future studies.
Details
- Title: Subtitle
- Complex roles of PIP2 in the regulation of ion channels and transporters
- Creators
- Chou-Long Huang - The University of Texas Southwestern Medical Center
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Renal physiology, Vol.293(6), pp.F1761-1765
- DOI
- 10.1152/ajprenal.00400.2007
- PMID
- 17928411
- ISSN
- 1931-857X
- eISSN
- 1522-1466
- Grant note
- R01-DK-59530 / NIDDK NIH HHS
- Language
- English
- Date published
- 12/2007
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984359583602771
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