Journal article
Complex segregation analysis of 1,792 cleft lip and palate families in South America: 1967-1997
Pesquisa odontológica brasileira, Vol.17(2), pp.161-165
04/2003
DOI: 10.1590/S1517-74912003000200012
PMID: 14569360
Abstract
Although several studies have demonstrated familial aggregation of nonsyndromic cleft lip with or without cleft palate (CL/P), its model of inheritance remains uncertain. We report the results of complex segregation analysis performed in South American families with a newborn affected with CL/P. Families of 1,792 consecutive newborns affected with CL/P and registered during the period 1967 to 1997 were studied. A model that did not include a major locus was the best-fitting model for CL/P families. This result is in agreement with previous studies which showed a significant association of several putative susceptibility loci and CL/P, indicating that the genes involved in CL/P are likely to have only a very modest impact on disease risk.
Details
- Title: Subtitle
- Complex segregation analysis of 1,792 cleft lip and palate families in South America: 1967-1997
- Creators
- Alexandre Rezende Vieira - Department of Pediatrics, University of Iowa, USAPaul Anthony RomittiIêda Maria OrioliEduardo Enrique Castilla
- Resource Type
- Journal article
- Publication Details
- Pesquisa odontológica brasileira, Vol.17(2), pp.161-165
- DOI
- 10.1590/S1517-74912003000200012
- PMID
- 14569360
- NLM abbreviation
- Pesqui Odontol Bras
- ISSN
- 1517-7491
- eISSN
- 1807-3107
- Publisher
- Brazil
- Grant note
- RR03655 / NCRR NIH HHS
- Language
- English
- Date published
- 04/2003
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9983995019402771
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