Journal article
Complications and survival associated with operative procedures in patients with unresectable pancreatic head adenocarcinoma
Journal of surgical oncology, Vol.109(7), pp.697-701
06/01/2014
DOI: 10.1002/jso.23560
PMID: 24395080
Abstract
Background
Unresectable tumors of the pancreatic head are encountered in up to 20% of patients taken for resection. The objective of this study was to evaluate the complications and outcome associated with palliative surgical procedures to help guide management decisions in these patients.
Methods
Patients with pancreatic head adenocarcinoma taken to the operating room with curative intent who did not undergo pancreatectomy were evaluated.
Results
From 1997 to 2013, 50 patients were explored and found be unresectable due to M1 disease (n = 27, 54.0%) or vascular invasion (n = 23, 46.0%). Among unresectable patients, 34 (68.0%) had a palliative procedure performed including double bypass (n = 13), biliary bypass (n = 7), gastrojejunostomy (n = 5), or cholecystectomy (n = 9). Complications occurred in 22 patients (44.0%), and patients who had a palliative operation had a longer hospital stay and more major complications. Overall survival was reduced in patients treated with a palliative operation.
Conclusions
Despite advancements in endoscopic palliation, operative bypasses are still commonplace in patients with unresectable pancreatic head cancer. In this study, patients treated with operative procedures had a high rate of complications without a notable improvement in outcome. These findings highlight the importance of identifying unresectable disease prior to surgery and support a selective approach to palliative operations. J. Surg. Oncol 2014; 109:697–701. © 2014 Wiley Periodicals, Inc.
Details
- Title: Subtitle
- Complications and survival associated with operative procedures in patients with unresectable pancreatic head adenocarcinoma
- Creators
- Philip M Spanheimer - University of Iowa Hospitals, ClinicsAnthony R Cyr - University of Iowa Hospitals, ClinicsJunlin Liao - University of Iowa Hospitals, ClinicsFrederick C Johlin - University of Iowa Hospitals, ClinicsHisakazu Hoshi - University of Iowa Hospitals, ClinicsJames R Howe - University of Iowa Hospitals, ClinicsJames J Mezhir - University of Iowa Hospitals, Clinics
- Resource Type
- Journal article
- Publication Details
- Journal of surgical oncology, Vol.109(7), pp.697-701
- DOI
- 10.1002/jso.23560
- PMID
- 24395080
- ISSN
- 0022-4790
- eISSN
- 1096-9098
- Number of pages
- 5
- Language
- English
- Date published
- 06/01/2014
- Academic Unit
- Gastroenterology and Hepatology; Surgery; Internal Medicine
- Record Identifier
- 9984051583302771
Metrics
14 Record Views