Journal article
Composite Biclonal Marginal Zone Lymphoma of Lung and Chronic Lymphocytic Leukemia: Pathologic, Phenotypic, Cytogenetic, and Molecular Study
International journal of surgical pathology, Vol.19(3), pp.377-381
06/2011
DOI: 10.1177/1066896909332454
PMID: 19372083
Abstract
The simultaneous diagnosis of marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is rare. This study reports a patient with composite synchronous biclonal occurrence of MALT lymphoma of the lung and CLL/SLL. The morphology of the lung and peripheral blood showed features of MALT lymphoma and CLL, respectively. The cytogenetic evaluation of the lung specimen revealed a t(1;14) (p22;q32), a frequent genetic abnormality in MALT lymphoma. Flow cytometry analysis of the lung tissue showed features of MALT lymphoma and CLL/SLL with different light chain restriction, whereas the blood showed phenotypic evidence of CLL/SLL. Fluorescence in situ hybridization study of the blood showed a deletion of 13q14 and 17p13. Immunoglobulin heavy chain (IgH) gene rearrangement study of the lung tissue and blood showed a monoclonal IgH gene rearrangement with distinct light chain restriction, suggesting that the immunophenotypically different cell populations originated from separate clones.
Details
- Title: Subtitle
- Composite Biclonal Marginal Zone Lymphoma of Lung and Chronic Lymphocytic Leukemia: Pathologic, Phenotypic, Cytogenetic, and Molecular Study
- Creators
- Sharathkumar Bhagavathi - Department of Pathology, Indiana University, Indianapolis, Indiana (S Bhagavathi), , Department of Pathology, William Beaumont Hospital, Royal Oak, MichiganMark A Micale - William Beaumont Hospital, Royal Oak, MichiganVonda Douglas-Nikitin - William Beaumont Hospital, Royal Oak, MichiganSamer Ballouz - Department of Hematology/Oncology, William Beaumont Hospital, Royal Oak, MichiganKurt Neumann - William Beaumont Hospital, Royal Oak, MichiganAnn Marie Blenc - William Beaumont Hospital, Royal Oak, Michigan
- Resource Type
- Journal article
- Publication Details
- International journal of surgical pathology, Vol.19(3), pp.377-381
- DOI
- 10.1177/1066896909332454
- PMID
- 19372083
- ISSN
- 1066-8969
- eISSN
- 1940-2465
- Language
- English
- Date published
- 06/2011
- Academic Unit
- Pathology
- Record Identifier
- 9984046821502771
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