Journal article
Composite Hyaluronic Acid Gas-Entrapping Materials to Promote Wound Healing
Biomacromolecules, Vol.26(1), pp.201-208
01/13/2025
DOI: 10.1021/acs.biomac.4c00904
PMCID: PMC11733945
PMID: 39746190
Appears in UI Libraries Support Open Access
Abstract
Tissue repair is often impaired in pathological states, highlighting the need for innovative wound-healing technologies. This study introduces composite hyaluronic acid gas-entrapping materials (GEMs) delivering carbon monoxide (CO) to promote wound healing in pigs. These composite materials facilitate burst release followed by sustained release of CO over 48 h. In a porcine full-thickness wound model, CO-GEMs significantly accelerated wound closure compared to the standard-of-care dressing (Tegaderm). Wound area closure with CO-GEMs was 68.6% vs 56.8% on day 14, 41.0% vs 25.1% on day 28, and 26.9% vs 11.8% on day 42, effectively reducing healing time by 14 days. Histological analysis revealed increased epithelialization and neovascularization with reduced inflammation. These findings demonstrate the potential of CO-GEMs as a topical therapeutic to enhance tissue repair in clinically relevant models, supporting further testing for wound-healing applications.
Details
- Title: Subtitle
- Composite Hyaluronic Acid Gas-Entrapping Materials to Promote Wound Healing
- Creators
- Emily Witt - University of IowaEmily B Petersen - University of IowaEyas Alzayadneh - University of IowaRyan J Courtney - University of IowaMarc J Brouillette - University of IowaQi Wang - University of IowaMaxwell Y Sakyi - University of IowaNicole A D Watson - University of IowaDominic Rivas - University of IowaJianling Bi - Department of Radiation Oncology, University of Iowa, Iowa City, Iowa 52242, United StatesLindsey Culver - University of IowaKyle Balk - University of IowaColin Reis - Department of Radiation Oncology, University of Iowa, Iowa City, Iowa 52242, United StatesSlyn Uaroon - University of IowaKaitlyn A McClintic - University of IowaSamual Hatfield - University of IowaKristan S Worthington - University of IowaEdward A Sander - University of IowaGiovanni Traverso - Brigham and Women's HospitalLeo E Otterbein - Beth Israel Deaconess Medical CenterJessica E Goetz - University of IowaDouglas C Fredericks - University of IowaJames D Byrne - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Biomacromolecules, Vol.26(1), pp.201-208
- DOI
- 10.1021/acs.biomac.4c00904
- PMID
- 39746190
- PMCID
- PMC11733945
- NLM abbreviation
- Biomacromolecules
- ISSN
- 1526-4602
- eISSN
- 1526-4602
- Publisher
- American Chemical Society; WASHINGTON
- Grant note
- University of Iowa Hospitals and Clinics Department of Radiation OncologyHolden Comprehensive Cancer Center at the University of IowaNational Institutes of Health (NIH) National Cancer Institute (NCI): P30CA086862 NCI: K08CA276908 American Cancer Society: IRG-21-141-46 Prostate Cancer Foundation Young Investigator AwardDepartment of Defense Prostate Cancer Program Early Investigator Award: W81XWH-20-1-0225
This work was funded in part by grants from the University of Iowa Hospitals and Clinics Department of Radiation Oncology and the Holden Comprehensive Cancer Center at the University of Iowa and its National Institutes of Health (NIH) National Cancer Institute (NCI) awards P30CA086862(JDB), NCI K08CA276908 (JDB), American Cancer Society IRG-21-141-46 (JDB), Prostate Cancer Foundation Young Investigator Award (JDB), and Department of Defense Prostate Cancer Program Early Investigator Award W81XWH-20-1-0225 (JDB).
- Language
- English
- Electronic publication date
- 01/02/2025
- Date published
- 01/13/2025
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute; Orthopedics and Rehabilitation; Radiation Oncology; Craniofacial Anomalies Research Center; Chemical and Biochemical Engineering; Otolaryngology
- Record Identifier
- 9984769723702771
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