Journal article
Comprehensive Compilation of Congener Profiles to Support Health Assessment of Environmental Exposures to Polychlorinated Biphenyl Mixtures
Environmental research, Vol.263(Part 1), 120081
12/15/2024
DOI: 10.1016/j.envres.2024.120081
PMCID: PMC11608150
PMID: 39343341
Abstract
Exposure to polychlorinated biphenyls (PCBs) remains a potential human health risk due to their persistence in the environment, despite a global ban on their production. Understanding the composition of PCB mixtures is essential for the application of a mixtures-based approach to assessing health risks of PCB exposure. This work represents the most extensive effort to date to compile and make publicly available the PCB congener profiles for mixtures with toxicological data, providing a foundation for understanding toxicological potency of PCB mixtures in the environment. We identified published congener profiles across 29 commercial and simulated environmental PCB mixtures, including various Aroclors, Phenoclors, Clophens, and Kanechlors, among others. A total of 117 references containing 401 distinct complete or partial tabularized profiles were found. Aroclor 1254 had the most published profiles, with 79 unique datasets characterizing multiple mixture lots. In contrast, no congener-specific composition data were identified for Fenclors, Clophen C, or Pyralenes. Eighty-seven of the most complete and clearly reported profiles underwent a detailed extraction of the congener data, PCB mixture source, and analytical methods. Challenges encountered during data extraction included congener coelutions, incomplete methods reporting, and inconsistencies in PCB nomenclature. These factors complicate data visualization, comparisons across datasets, and use of the data in subsequent analyses. Where possible, we have converted profiles to the same units and congener numbering convention to allow for easier comparison. The extracted data are publicly available online as interactive visuals and as a downloadable Microsoft Excel® workbook. This dataset provides researchers with an overview of the current PCB mixture profile landscape that can serve as a tool to support efforts to minimize the health impacts of environmental PCB exposure, including the exploration of links between mixture composition and toxicity and the identification of the most efficient and effective remediation strategies at contaminated sites.
Details
- Title: Subtitle
- Comprehensive Compilation of Congener Profiles to Support Health Assessment of Environmental Exposures to Polychlorinated Biphenyl Mixtures
- Creators
- Brittany Schulz - Oak Ridge Associated UniversitiesLaura M. Carlson - Environmental Protection AgencyKrista Christensen - Environmental Protection AgencyChelsea A. Weitekamp - Environmental Protection AgencyRachel F. Marek - University of IowaAndres Martinez - University of IowaKeri C. Hornbuckle - University of IowaGeniece M. Lehmann - Environmental Protection Agency
- Resource Type
- Journal article
- Publication Details
- Environmental research, Vol.263(Part 1), 120081
- DOI
- 10.1016/j.envres.2024.120081
- PMID
- 39343341
- PMCID
- PMC11608150
- NLM abbreviation
- Environ Res
- ISSN
- 0013-9351
- eISSN
- 1096-0953
- Publisher
- Elsevier Inc
- Grant note
- U.S. Environmental Protection Agency: 68HERC19D0003 National Institute of Environmental Health Sciences of the National Institutes of Health (NIEHS/NIH): P42ES013661
The views expressed are those of the authors and do not necessarily represent the views or policies of the U.S. Environmental Protection Agency. Any mention of trade names, products, or services does not imply an endorsement by the U.S. Government or the U.S. Environmental Protection Agency. The U.S. Environmental Protection Agency does not endorse any commercial products, services, or enterprises. Contributions from RFM, AM, and KCH were supported by the U.S. Environmental Protection Agency under Contract 68HERC19D0003 to ICF and by the National Institute of Environmental Health Sciences of the National Institutes of Health (NIEHS/NIH) Grant P42ES013661.
- Language
- English
- Electronic publication date
- 09/27/2024
- Date published
- 12/15/2024
- Academic Unit
- Civil and Environmental Engineering; Occupational and Environmental Health; IIHR--Hydroscience and Engineering; Interdisciplinary Graduate Program in Human Toxicology; Iowa Superfund Research Program
- Record Identifier
- 9984719802602771
Metrics
67 Record Views