Journal article
Comprehensive imaging analysis of intracranial atherosclerosis
Journal of neurointerventional surgery, Vol.17(3), pp.311-320
03/2025
DOI: 10.1136/jnis-2023-020622
PMID: 38719445
Abstract
Intracranial atherosclerotic disease (ICAD) involves the build-up of atherosclerotic plaques in cerebral arteries, significantly contributing to stroke worldwide. Diagnosing ICAD entails various techniques that measure arterial stenosis severity. Digital subtraction angiography, CT angiography, and magnetic resonance angiography are established methods for assessing stenosis. High-resolution MRI offers additional insights into plaque morphology including plaque burden, hemorrhage, remodeling, and contrast enhancement. These metrics and plaque traits help identify symptomatic plaques. Techniques like transcranial Doppler, CT perfusion, computational fluid dynamics, and quantitative MRA analyze blood flow restrictions due to ICAD. Intravascular ultrasound or optical coherence tomography have a very high spatial resolution and can assess the structure of the arterial wall and the plaque from the lumen of the target vascular territory. Positron emission tomography could further detect inflammation markers. This review aims to provide a comprehensive overview of the spectrum of current modalities for atherosclerotic plaque analysis and risk stratification.
Details
- Title: Subtitle
- Comprehensive imaging analysis of intracranial atherosclerosis
- Creators
- Sebastian Sanchez - Yale UniversityMahmud Mossa-Basha - University of WashingtonVania Anagnostakou - University of Massachusetts Chan Medical SchoolDavid S Liebeskind - University of California, Los AngelesEdgar A Samaniego - University of Iowa Hospitals and Clinics
- Contributors
- Liz Stockman (Editor)
- Resource Type
- Journal article
- Publication Details
- Journal of neurointerventional surgery, Vol.17(3), pp.311-320
- DOI
- 10.1136/jnis-2023-020622
- PMID
- 38719445
- NLM abbreviation
- J Neurointerv Surg
- ISSN
- 1759-8478
- eISSN
- 1759-8486
- Publisher
- BMJ Publishing Group Ltd
- Grant note
- 1S10OD025025-01 / Common Fund (http://dx.doi.org/10.13039/100015326)
- Language
- English
- Electronic publication date
- 05/06/2024
- Date published
- 03/2025
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984623025002771
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