Comprehensive resequence analysis of a 97 kb region of chromosome 10q11.2 containing the MSMB gene associated with prostate cancer

Meredith Yeager; Zuoming Deng; Joseph Boland; Casey Matthews; Jennifer Bacior; Victor Lonsberry; Amy Hutchinson; Laura A Burdett; Liqun Qi; Kevin B Jacobs; Jesus Gonzalez-Bosquet; Sonja I Berndt; Richard B Hayes; Robert N Hoover; Gilles Thomas; David J Hunter; Michael Dean; Stephen J Chanock

doi:10.1007/s00439-009-0723-9

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Comprehensive resequence analysis of a 97 kb region of chromosome 10q11.2 containing the MSMB gene associated with prostate cancer

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Comprehensive resequence analysis of a 97 kb region of chromosome 10q11.2 containing the MSMB gene associated with prostate cancer

Meredith Yeager, Zuoming Deng, Joseph Boland, Casey Matthews, Jennifer Bacior, Victor Lonsberry, Amy Hutchinson, Laura A Burdett, Liqun Qi, Kevin B Jacobs, …

Human genetics, Vol.126(6), pp.743-750

12/2009

DOI: 10.1007/s00439-009-0723-9

PMCID: PMC2778717

PMID: 19644707

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Abstract

Genome-wide association studies of prostate cancer have identified single nucleotide polymorphism (SNP) markers in a region of chromosome 10q11.2, harboring the microseminoprotein-β (MSMB) gene. Both the gene product of MSMB, the prostate secretory protein 94 (PSP94) and its binding protein (PSPBP), have been previously investigated as serum biomarkers for prostate cancer progression. Recent functional work has shown that different alleles of the significantly associated SNP in the promoter of MSMB found to be associated with prostate cancer risk, rs10993994, can influence its expression in tumors and in vitro studies. Since it is plausible that additional variants in this region contribute to the risk of prostate cancer, we have used next-generation sequencing technology to resequence a ~97-kb region that includes the area surrounding MSMB (chr10: 51,168,025-51,265,101) in 36 prostate cancer cases, 26 controls of European origin, and 8 unrelated CEPH individuals in order to identify additional variants to investigate in functional studies. We identified 241 novel polymorphisms within this region, including 142 in the 51-kb block of linkage disequilibrium (LD) that contains rs10993994 and the proximal promoter of MSMB. No sites were observed to be polymorphic within the exons of MSMB.

Prostatic Secretory Proteins - genetics

Genetic Predisposition to Disease

Prostatic Neoplasms - genetics

Humans

Genotype

Male

Chromosomes, Human, Pair 10

Sequence Analysis, DNA - methods

Linkage Disequilibrium

Polymorphism, Genetic

Details

Title: Subtitle: Comprehensive resequence analysis of a 97 kb region of chromosome 10q11.2 containing the MSMB gene associated with prostate cancer
Creators: Meredith Yeager - Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD 21702, USA. yeagerm@mail.nih.gov
Zuoming Deng
Joseph Boland
Casey Matthews
Jennifer Bacior
Victor Lonsberry
Amy Hutchinson
Laura A Burdett
Liqun Qi
Kevin B Jacobs
Jesus Gonzalez-Bosquet
Sonja I Berndt
Richard B Hayes
Robert N Hoover
Gilles Thomas
David J Hunter
Michael Dean
Stephen J Chanock
Resource Type: Journal article
Publication Details: Human genetics, Vol.126(6), pp.743-750
DOI: 10.1007/s00439-009-0723-9
PMID: 19644707
PMCID: PMC2778717
NLM abbreviation: Hum Genet
ISSN: 1432-1203
eISSN: 1432-1203
Publisher: Germany
Grant note: HHSN261200800001C / CCR NIH HHS HHSN261200800001E / NCI NIH HHS
Language: English
Date published: 12/2009
Academic Unit: Obstetrics and Gynecology
Record Identifier: 9983930274602771

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