Journal article
Computational identification of operon-like transcriptional loci in eukaryotes
Computers in Biology and Medicine, Vol.43(6), pp.738-743
07/01/2013
DOI: 10.1016/j.compbiomed.2013.03.004
PMID: 23668349
Abstract
Operons are primarily a bacterial phenomenon, not commonly observed in eukaryotes. However, new research indicates that operons are found in higher organisms as well. There are instances of operons found in C. elegans, Drosophila melanogaster and other eukaryotic species. We developed a prototype using positional, structural and gene expression information to identify candidate operons. We focused our efforts on “trans-spliced” operons in which the pre-mRNA is trans-spliced into individual transcripts and subsequently translated, as widely observed in C. elegans and some instances in Drosophila. We identify several candidate operons in Drosophila melanogaster of which two have been subsequently molecularly validated.
Details
- Title: Subtitle
- Computational identification of operon-like transcriptional loci in eukaryotes
- Creators
- Kishore Nannapaneni - Center for Bioinformatics and Computational Biology, University of Iowa, Iowa City, IA 52242, USAYehuda Ben-Shahar - Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USAHenry L Keen - Center for Bioinformatics and Computational Biology, University of Iowa, Iowa City, IA 52242, USAMichael J Welsh - Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, USAThomas L Casavant - Center for Bioinformatics and Computational Biology, University of Iowa, Iowa City, IA 52242, USATodd E Scheetz - Center for Bioinformatics and Computational Biology, University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Computers in Biology and Medicine, Vol.43(6), pp.738-743
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.compbiomed.2013.03.004
- PMID
- 23668349
- ISSN
- 0010-4825
- eISSN
- 1879-0534
- Language
- English
- Date published
- 07/01/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Electrical and Computer Engineering; Molecular Physiology and Biophysics; Neurosurgery; Internal Medicine; Ophthalmology and Visual Sciences; Iowa Institute of Human Genetics
- Record Identifier
- 9983979972802771
Metrics
20 Record Views