Journal article
Computed Tomographic-Based Quantification of Emphysema and Correlation to Pulmonary Function and Mechanics
Chronic obstructive pulmonary disease, Vol.5(3), pp.177-186
06/01/2008
DOI: 10.1080/15412550802093025
PMID: 18568842
Abstract
Computed tomographic based indices of emphysematous lung destruction may highlight differences in disease pathogenesis and further enable the classification of subjects with Chronic Obstructive Pulmonary Disease. While there are multiple techniques that can be utilized for such radiographic analysis, there is very little published information comparing the performance of these methods in a clinical case series. Our objective was to examine several quantitative and semi-quantitative methods for the assessment of the burden of emphysema apparent on computed tomographic scans and compare their ability to predict lung mechanics and function. Automated densitometric analysis was performed on 1094 computed tomographic scans collected upon enrollment into the National Emphysema Treatment Trial. Trained radiologists performed an additional visual grading of emphysema on high resolution CT scans. Full pulmonary function test results were available for correlation, with a subset of subjects having additional measurements of lung static recoil. There was a wide range of emphysematous lung destruction apparent on the CT scans and univariate correlations to measures of lung function were of modest strength. No single method of CT scan analysis clearly outperformed the rest of the group. Quantification of the burden of emphysematous lung destruction apparent on CT scan is a weak predictor of lung function and mechanics in severe COPD with no uniformly superior method found to perform this analysis. The CT based quantification of emphysema may augment pulmonary function testing in the characterization of COPD by providing complementary phenotypic information.
Details
- Title: Subtitle
- Computed Tomographic-Based Quantification of Emphysema and Correlation to Pulmonary Function and Mechanics
- Creators
- George R. Washko - Brigham and Women's HospitalGerald J. Criner - Temple University HospitalZab Mohsenifar - Cedars-Sinai Medical CenterFrank C. Sciurba - University of PittsburghAmir Sharafkhaneh - Baylor College of MedicineBarry J. Make - National Jewish HealthEric A. Hoffman - University of IowaJohn J. Reilly - Brigham and Women's HospitalNational Emphysema Treatment Trial (NETT) Research Group
- Resource Type
- Journal article
- Publication Details
- Chronic obstructive pulmonary disease, Vol.5(3), pp.177-186
- DOI
- 10.1080/15412550802093025
- PMID
- 18568842
- NLM abbreviation
- COPD
- ISSN
- 1541-2555
- eISSN
- 1541-2563
- Publisher
- Taylor & Francis
- Number of pages
- 10
- Grant note
- N01HR076110 / DIVISION OF LUNG DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) T32 HL007633 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Centers for Medicare and Medicaid Services (CMS); Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT); CONICYT PIA/BASAL Agency for Healthcare Research and Quality (AHRQ); United States Department of Health & Human Services; Agency for Healthcare Research & Quality U10HL074428; N01HR76101; N01HR76102; N01HR76103; N01HR76104; N01HR76105; N01HR76106; N01HR76107; N01HR76108; N01HR76109; N01HR76110; N01HR76111; N01HR76112; N01HR76113; N01HR76114; N01HR76115; N01HR76116; N01HR76118; N01HR76119 / National Heart, Lung, and Blood Institute (NHLBI); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) T32HL007633 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 06/01/2008
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984318809402771
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