Journal article
Computed Tomographic Scoring Systems in Sarcoidosis: Comparison With Cardiopulmonary Exercise Testing Parameters
Journal of thoracic imaging, Vol.31(2), pp.104-110
03/2016
DOI: 10.1097/RTI.0000000000000198
PMID: 26891073
Abstract
The aim of the study was to correlate computed tomographic (CT) scoring systems for pulmonary sarcoidosis with cardiopulmonary exercise testing and evaluate which scoring system provides the most reliable information for assessing disease severity and predicting impairment of gas exchange during exercise.
The institutional review board approved this retrospective study. All 62 patients underwent thin-section CT, pulmonary function tests, and cardiopulmonary exercise test. Two observers scored CT images according to scoring systems published by Remy-Jardin and colleagues. Spearman rank correlation coefficients were calculated between CT patterns and pulmonary functional impairment parameters, and multiple regression analyses were performed to evaluate which CT abnormalities were significantly associated with pulmonary functional impairment parameters.
Regardless of scoring system, PaO2max was significantly associated with the subscores of ground-glass opacity, linear opacity, and total CT scores. Multiple regression analyses showed that subscores of ground-glass and linear opacity in the Leung scoring system appeared to explain a significant amount of variance in functional parameters at rest and at maximal exercise.
CT findings, particularly ground-glass opacity and linear abnormalities, can explain a significant amount of variance in cardiopulmonary exercise parameters. This suggests that CT-based scoring systems are valid measures of disease severity in sarcoidosis.
Details
- Title: Subtitle
- Computed Tomographic Scoring Systems in Sarcoidosis: Comparison With Cardiopulmonary Exercise Testing Parameters
- Creators
- Yeon Joo Jeong - Departments of Radiology †Medicine, Division of Pulmonary and Critical Care Sciences, National Jewish Health, University of Colorado Denver School of Medicine, Denver, CO ‡Department of Biomedical Sciences, School of Medicine, Inha University, Incheon, KoreaDavid A LynchJi Young RhoNabeel Y HamzehYoung Ju Suh
- Resource Type
- Journal article
- Publication Details
- Journal of thoracic imaging, Vol.31(2), pp.104-110
- DOI
- 10.1097/RTI.0000000000000198
- PMID
- 26891073
- ISSN
- 0883-5993
- eISSN
- 1536-0237
- Language
- English
- Date published
- 03/2016
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984094371302771
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