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Computed Tomography Studies of Lung Ventilation and Perfusion
Journal article   Open access

Computed Tomography Studies of Lung Ventilation and Perfusion

Eric A Hoffman and Deokiee Chon
Proceedings of the American Thoracic Society, Vol.2(6), pp.492-498
12/2005
DOI: 10.1513/pats.200509-099DS
PMCID: PMC2713338
PMID: 16352755
url
https://doi.org/10.1513/pats.200509-099DSView
Published (Version of record) Open Access

Abstract

With the emergence of multidetector-row computed tomography (CT) it is now possible to image both structure and function via use of a single imaging modality. Breath-hold spiral CT provides detail of the airway and vascular trees along with texture reflective of the state of the lung parenchyma. Use of stable xenon gas wash-in and/or wash-out methods using an axial mode of the CT scanner whereby images are acquired through gating to the respiratory cycle provide detailed images of regional ventilation with isotropic voxel dimensions now on the order of 0.4 mm. Axial scanning during a breath hold and gating to the electrocardiogram during the passage of a sharp bolus injection of iodinated contrast agent provide detailed images of regional pulmonary perfusion. These dynamic CT methods for the study of regional lung function are discussed in the context of other methods that have been used to study heterogeneity of lung function.
 Edwin J. R. Van Beek, M.d., Ph.d pulmonary perfusion Functional Imaging pulmonary blood flow pulmonary ventilation Section Editor computed tomography, functional, quantitative, xenon

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