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Computerized Cognitive Training in Amnestic Mild Cognitive Impairment: A Randomized Clinical Trial
Journal article   Peer reviewed

Computerized Cognitive Training in Amnestic Mild Cognitive Impairment: A Randomized Clinical Trial

Kevin Duff, Jian Ying, Kayla R Suhrie, Bonnie C A Dalley, Taylor J Atkinson, Sariah M Porter, Ava M Dixon, Dustin B Hammers and Fredric D Wolinsky
Journal of geriatric psychiatry and neurology, Vol.35(3), pp.400-409
05/2022
DOI: 10.1177/08919887211006472
PMID: 33783254

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Abstract

Computerized cognitive training has been successful in healthy older adults, but its efficacy has been mixed in patients with amnestic Mild Cognitive Impairment (MCI). In a randomized, placebo-controlled, double-blind, parallel clinical trial, we examined the short- and long-term efficacy of a brain-plasticity computerized cognitive training in 113 participants with amnestic MCI. Immediately after 40-hours of training, participants in the active control group who played computer games performed better than those in the experimental group on the primary cognitive outcome (p = 0.02), which was an auditory memory/attention composite score. There were no group differences on 2 secondary outcomes (global cognitive composite and rating of daily functioning). After 1 year, there was no difference between the 2 groups on primary or secondary outcomes. No adverse events were noted. Although the experimental cognitive training program did not improve outcomes in those with MCI, the short-term effects of the control group should not be dismissed, which may alter treatment recommendations for these patients.
 Aged Attention Cognition Cognition Disorders Cognitive Dysfunction - psychology Cognitive Dysfunction - therapy Double-Blind Method Humans Neuropsychological Tests Treatment Outcome

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