Journal article
Concomitant alterations of physiological and developmental plasticity in drosophila CaM kinase II-inhibited synapses
Neuron (Cambridge, Mass.), Vol.13(6), pp.1373-1384
12/1994
DOI: 10.1016/0896-6273(94)90422-7
PMID: 7993628
Abstract
Ca2+/calmodulin-dependent protein kinase II (CaM kinase) has been implicated in neural plasticity that underlies learning and memory processes. Transformed strains of Drosophila, alI and al2, expressing a specific inhibitor of CaM kinase are known to be impaired in an associative conditioning behavioral paradigm. We found that these transformants had altered short-term plasticity in synaptic transmission along with abnormal nerve terminal sprouting and directionality of outgrowth. These results represent an interesting parallel with the activity-dependent regulation of synaptic physiology and morphology by the cAMP cascade in Aplysia and Drosophila. In contrast to the learning mutants dunce and rutabaga, which are defective in the cAMP cascade, inhibition of CaM kinase in al transformants caused increased sprouting at larval neuromuscular junctions near the nerve entry point, rather than altering the higher order branch segments. In addition, synaptic facilitation and potentiation were altered in a manner different from that observed in the cAMP mutants. Furthermore, synaptic currents in ala transformants were characterized by greater variability, suggesting an important role of CaM kinase in the stability of transmission.
Details
- Title: Subtitle
- Concomitant alterations of physiological and developmental plasticity in drosophila CaM kinase II-inhibited synapses
- Creators
- Jing Wang - Department of Biological Sciences University of Iowa Iowa City, Iowa 52242John I Renger - Department of Biological Sciences University of Iowa Iowa City, Iowa 52242Leslie C Griffith - Department of Biology and Center for Complex Systems Brandeis University Waltham, Massachusetts 02254Ralph J Greenspan - Department of Biology and Center for Neural Science New York University New York, New York 10003Chun-Fang Wu - Department of Biological Sciences University of Iowa Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- Neuron (Cambridge, Mass.), Vol.13(6), pp.1373-1384
- DOI
- 10.1016/0896-6273(94)90422-7
- PMID
- 7993628
- NLM abbreviation
- Neuron
- ISSN
- 0896-6273
- eISSN
- 1097-4199
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 12/1994
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9984070213702771
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