Journal article
Concomitant progressive supranuclear palsy and multiple system atrophy: A rare case report of tauopathy and synucleinopathy interface
Journal of neuroradiology, Vol.52(4), 101347
06/2025
DOI: 10.1016/j.neurad.2025.101347
PMID: 40300288
Abstract
Progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) are neurodegenerative disorders characterized by parkinsonian symptoms. PSP typically presents with supranuclear gaze palsy, postural instability, and subcortical dementia, while dysautonomia and cerebellar signs are hallmark features of MSA. We report the case of a 77-year-old male patient with a four-year history of progressive parkinsonian symptoms that have shown poor response to treatment. His clinical manifestations included bradykinesia, rigidity, swallowing difficulties, urinary frequency, nocturia, downward gaze palsy, hypometric saccades, and finger-nose dysmetria. Examination revealed increased tone in both upper extremities, more pronounced on the right side, along with bradykinesia, slow hand movements, and bilateral decrement in finger tapping. Brain magnetic resonance imaging (MRI) revealed mixed MRI findings consistent with atypical parkinsonian syndrome, showing signs of MSA-C with pontocerebellar atrophy and the "hot cross bun" sign, as well as PSP with midbrain atrophy (hummingbird sign) and tegmental hypersignal.
Details
- Title: Subtitle
- Concomitant progressive supranuclear palsy and multiple system atrophy: A rare case report of tauopathy and synucleinopathy interface
- Creators
- Nitesh Shekhrajka - University of IowaMárcio Luís Duarte - Universidade de Ribeirão PretoLeonardo Furtado Freitas - Division of Neuroradiology, Department of Radiology, Baptist Health of South Florida / Radiology Associates of South Florida (RASF) / Florida International University (FIU) - Herbert Wertheim College of Medicine, Miami, USA. Electronic address: drleonardofurtado@gmail.com
- Resource Type
- Journal article
- Publication Details
- Journal of neuroradiology, Vol.52(4), 101347
- Publisher
- MASSON EDITEUR
- DOI
- 10.1016/j.neurad.2025.101347
- PMID
- 40300288
- ISSN
- 0150-9861
- eISSN
- 1773-0406
- Language
- English
- Electronic publication date
- 04/28/2025
- Date published
- 06/2025
- Academic Unit
- Radiology
- Record Identifier
- 9984816012402771
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