Journal article
Concordance between head and neck MRI and histopathology in detecting laryngeal subsite invasion among patients with laryngeal cancer
Cancer imaging, Vol.23(1), pp.1-99
10/19/2023
DOI: 10.1186/s40644-023-00618-y
PMCID: PMC10585883
PMID: 37858162
Abstract
Background Accuracy of head and neck MRI (HN-MRI) in predicting tumor invasion of laryngeal site/subsites in patients with laryngeal cancer prior to laryngectomy is poorly evaluated in the literature. Therefore, we aim to evaluate the diagnostic value of HN-MRI in accurate pre-operative estimation of tumor invasion to laryngeal subsites in patients with laryngeal cancer.Methods Patients with laryngeal cancer who underwent HN-MRI for cancer staging and underwent total laryngectomy between 2008 and 2021 were included. Sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy of HN-MRI in predicting tumor invasion of laryngeal subsites were calculated based on concordance between the HN-MRI and histopathological results.Results One hundred and thirty-seven patients underwent total laryngectomy [primary: 82/137(60%), salvage 55/137(40%)]. The utilization of HN-MRI resulted in the downstaging of 16/137 (11.6%) patients and the upstaging of 8/137 (5.8%) patients. For the whole cohort, there was a significant discordance between HN-MRI and histopathology for T-category; out of 116 cT4a disease, 102(87.9%) were confirmed to have pT4a disease, and out of 17 cT3 disease, 9(52.9%) were confirmed to have pT3 disease, p < 0.001. The MRI overall diagnostic accuracy of predicting tumor invasion was 91%, 92%, 82%, 87%, 72%, 76%, 65% and 68% for base of tongue, arytenoid, vocal cord, posterior commissure, pre-epiglottic space, cricoid cartilage, inner thyroid cortex, and subglottis, respectively.Conclusions In patients with laryngeal cancer undergoing total laryngectomy, HN-MRI demonstrates promising accuracy in predicting tumor invasion of specific laryngeal subsites (e.g., base of tongue). Our findings showed the potential of HN-MRI as a valuable tool for pre-operative planning and treatment decision-making in this patient population.
Details
- Title: Subtitle
- Concordance between head and neck MRI and histopathology in detecting laryngeal subsite invasion among patients with laryngeal cancer
- Creators
- Issa Mohamad - King Hussein Cancer CenterTaher Abu Hejleh - King Hussein Canc Ctr, Dept Med Oncol, Amman, JordanMonther Qandeel - King Hussein Cancer CenterMaysa Al-Hussaini - King Hussein Canc Ctr, Dept Pathol & Lab Med, Amman, JordanSami Koro - Cleveland ClinicAyat Taqash - King Hussein Cancer CenterAbdelatif Almousa - King Hussein Cancer CenterFawzi Abuhijla - King Hussein Cancer CenterRamiz Abuhijlih - King Hussein Canc Ctr, Dept Radiat Oncol, Amman, JordanFatenah Ajlouni - King Hussein Canc Ctr, Dept Diagnost Radiol, Amman, JordanAkram Al-Ibraheem - King Hussein Canc Ctr, Dept Nucl Med, Amman, JordanDima Abu Laban - King Hussein Canc Ctr, Dept Diagnost Radiol, Amman, JordanTariq Hussein - King Hussein Cancer CenterEbrahim Mayta - King Hussein Cancer CenterWisam Al-Gargaz - King Hussein Canc Ctr, Dept Surg Oncol, Amman, JordanAli Hosni - Princess Margaret Cancer Centre
- Resource Type
- Journal article
- Publication Details
- Cancer imaging, Vol.23(1), pp.1-99
- Publisher
- Springer Nature
- DOI
- 10.1186/s40644-023-00618-y
- PMID
- 37858162
- PMCID
- PMC10585883
- ISSN
- 1740-5025
- eISSN
- 1470-7330
- Number of pages
- 9
- Grant note
- None.
- Language
- English
- Date published
- 10/19/2023
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Radiation Oncology; Internal Medicine
- Record Identifier
- 9984697642202771
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