Journal article
Concurrent measurement of substance P and serotonin in spinal superfusates: failure of capsaicin and p-chloroamphetamine to co-release
Brain research, Vol.270(1), pp.181-184
1983
DOI: 10.1016/0006-8993(83)90812-0
PMID: 6191841
Abstract
This study examined the efflux of endogenous serotonin and substance P-like immunoreactive material into in vivo superfusates of the rat spinal cord under quiescent conditions and during the addition of either capsaicin or
p-chloroamphetamine to the superfusate. Using a method which permitted concurrent measurement of serotonin and substance P-like immunoreactive material in the same sample of superfusate, it was found that capsaicin increased the efflux of substance P-like immunoreactive material from the spinal cord but did not alter the efflux of serotonin. Conversely, the addition of
p-chloroamphetamine caused the efflux of serotonin from the spinal cord to increase, but did not affect the efflux of substance P-like immunoreactive material.
Details
- Title: Subtitle
- Concurrent measurement of substance P and serotonin in spinal superfusates: failure of capsaicin and p-chloroamphetamine to co-release
- Creators
- Lena Bergstrom - Department of Pharmacology, Uppsala University, Uppsala SwedenDonna L Hammond - Department of Neurosurgery Research Mayo Clinic and Mayo Foundation, Rochester, MO 55905 U.S.AVay L.W Go - Department of Gastrointestinal Research, Mayo Clinic and Mayo Foundation, Rochester, MO 55905 U.S.ATony L Yaksh - Department of Neurosurgery Research Mayo Clinic and Mayo Foundation, Rochester, MO 55905 U.S.A
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.270(1), pp.181-184
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0006-8993(83)90812-0
- PMID
- 6191841
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 1983
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Anesthesia; Neuroscience and Pharmacology
- Record Identifier
- 9984006481902771
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