Journal article
Conformational control through translocational regulation: a new view of secretory and membrane protein folding
BioEssays, Vol.24(8), pp.741-748
08/2002
DOI: 10.1002/bies.10130
PMID: 12210535
Abstract
We suggest a new view of secretory and membrane protein folding that emphasizes the role of pathways of biogenesis in generating functional and conformational heterogeneity. In this view, heterogeneity results from action of accessory factors either directly binding specific sequences of the nascent chain, or indirectly, changing the environment in which a particular domain is synthesized. Entrained by signaling pathways, these variables create a combinatorial set of necessary-but-not-sufficient conditions that enhance synthesis and folding of particular alternate, functional, conformational forms. We therefore propose that protein conformation is productively regulated by the cell during translocation across the endoplasmic reticulum (ER), a concept that may account for currently poorly understood aspects of physiological function, natural selection, and disease pathogenesis.
Details
- Title: Subtitle
- Conformational control through translocational regulation: a new view of secretory and membrane protein folding
- Creators
- Vishwanath R Lingappa - Department of Physiology, University of California, San FranciscoD. Thomas Rutkowski - Department of Biochemistry and Biophysics, University of California, San FranciscoRamanujan S Hegde - Laboratory of Cellular Oncology, National Institutes of Health, BethesdaOlaf S Andersen - Department of Physiology and Biophysics, Weill Medical College of Cornell University
- Resource Type
- Journal article
- Publication Details
- BioEssays, Vol.24(8), pp.741-748
- DOI
- 10.1002/bies.10130
- PMID
- 12210535
- NLM abbreviation
- Bioessays
- ISSN
- 0265-9247
- eISSN
- 1521-1878
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- Number of pages
- 8
- Language
- English
- Date published
- 08/2002
- Academic Unit
- Anatomy and Cell Biology; Internal Medicine
- Record Identifier
- 9984094403802771
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