Congener-specific tissue distribution of aroclor 1254 and a highly chlorinated environmental PCB mixture in rats

Izabela Kania-Korwel; Keri C Hornbuckle; Aaron Peck; Gabriele Ludewig; Larry W Robertson; Wieslaw W Sulkowski; Parvaneh Espandiari; C Gary Gairola; Hans-Joachim Lehmler

doi:10.1021/es047987f

Back

Congener-specific tissue distribution of aroclor 1254 and a highly chlorinated environmental PCB mixture in rats

Journal article

Peer reviewed

Congener-specific tissue distribution of aroclor 1254 and a highly chlorinated environmental PCB mixture in rats

Izabela Kania-Korwel, Keri C Hornbuckle, Aaron Peck, Gabriele Ludewig, Larry W Robertson, Wieslaw W Sulkowski, Parvaneh Espandiari, C Gary Gairola and Hans-Joachim Lehmler

Environmental science & technology, Vol.39(10), pp.3513-3520

05/15/2005

DOI: 10.1021/es047987f

PMID: 15954224

View Online

Abstract

Polychlorinated biphenyl (PCB) mixtures were synthesized and marketed in Eastern European countries, but little is known abouttheir composition, distribution, ortoxicity. PCB-contaminated soil from the former production site of the Polish PCB mixture Chlorofen was collected, and the PCBs were extracted. An in vivo study was performed to investigate the PCB tissue distribution and biochemical effects of this soil extract in immature male Sprague-Dawley rats. Rats were administered 0.05 mmol/kg soil-extracted PCBs or Aroclor 1254 and sacrificed 7 days later, and congener-specific PCB profiles in selected tissues were determined. Distribution of SigmaPCBs (sum of 120 congeners) in tissues was primarily a function of lipid content of the tissues, except for the spleen, which retained more PCB than other tissues. Multivariate analysis of the PCB congener data showed that (a) congener profiles in tissues had changed, as compared to the parent mixture; (b) disposition and redistribution of individual congeners in vivo differed between both mixtures; and (c) more highly chlorinated congeners were retained in the spleens of both treatment groups. Differences in the induction of cytochrome P-450 1A and 2B subfamilies reflected the homologue composition of the respective mixtures and predict a different toxicity profile for Chlorofen than for Aroclor 1254.

Poland

Myocardium - chemistry

Lung - chemistry

Polychlorinated Biphenyls - blood

Male

Soil Pollutants - isolation & purification

Brain - metabolism

Tissue Distribution

Cytochrome P-450 CYP2B1 - metabolism

Microsomes, Liver - enzymology

Rats

Hazardous Waste

Polychlorinated Biphenyls - metabolism

Cytochrome P-450 CYP1A1 - metabolism

Soil Pollutants - blood

Rats, Sprague-Dawley

Liver - chemistry

Spleen - chemistry

Skin - chemistry

Soil Pollutants - metabolism

Animals

Kidney - chemistry

Adipose Tissue - chemistry

Lipids - analysis

Polychlorinated Biphenyls - isolation & purification

Details

Title: Subtitle: Congener-specific tissue distribution of aroclor 1254 and a highly chlorinated environmental PCB mixture in rats
Creators: Izabela Kania-Korwel - Department of Occupational and Environmental Health, College of Public Health, University of lowa, Iowa City, Iowa 52242, USA
Keri C Hornbuckle
Aaron Peck
Gabriele Ludewig
Larry W Robertson
Wieslaw W Sulkowski
Parvaneh Espandiari
C Gary Gairola
Hans-Joachim Lehmler
Resource Type: Journal article
Publication Details: Environmental science & technology, Vol.39(10), pp.3513-3520
DOI: 10.1021/es047987f
PMID: 15954224
NLM abbreviation: Environ Sci Technol
ISSN: 0013-936X
eISSN: 1520-5851
Publisher: United States
Grant note: P42 ES013661 / NIEHS NIH HHS ES07380 / NIEHS NIH HHS ES05605 / NIEHS NIH HHS ES12475 / NIEHS NIH HHS
Language: English
Date published: 05/15/2005
Academic Unit: Civil and Environmental Engineering; Occupational and Environmental Health; Iowa Neuroscience Institute
Record Identifier: 9983997426802771

Metrics

16 Record Views

35 Times Cited - Web of Science