Congeners of SMAP29 Kill Ovine Pathogens and Induce Ultrastructural Damage in Bacterial Cells

V. C Kalfa; H. P Jia; R. A Kunkle; P. B McCray; B. F Tack; K. A Brogden

doi:10.1128/AAC.45.11.3256-3261.2001

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Congeners of SMAP29 Kill Ovine Pathogens and Induce Ultrastructural Damage in Bacterial Cells

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Congeners of SMAP29 Kill Ovine Pathogens and Induce Ultrastructural Damage in Bacterial Cells

V. C Kalfa, H. P Jia, R. A Kunkle, P. B McCray, B. F Tack and K. A Brogden

Antimicrobial agents and chemotherapy, Vol.45(11), pp.3256-3261

Note

11/2001

DOI: 10.1128/AAC.45.11.3256-3261.2001

PMCID: PMC90821

PMID: 11600395

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Abstract

SMAP29, an ovine cathelicidin, was systematically altered to create a family of 23 related peptides for MIC and minimum bactericidal concentration determinations. SMAP28, SMAP29, and a derivative of SMAP29 called ovispirin were all antimicrobial. However, many congeners of SMAP29 and ovispirin were not as active as the parent molecules. With immunoelectron microscopy, SMAP29 was seen on membranes and within the cytoplasm of Pseudomonas aeruginosa PAO1.

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Title: Subtitle: Congeners of SMAP29 Kill Ovine Pathogens and Induce Ultrastructural Damage in Bacterial Cells
Creators: V. C Kalfa - Respiratory Diseases of Livestock Research Unit, USDA Agricultural Research Service, National Animal Disease Center, Ames, Iowa 50010
H. P Jia - Respiratory Diseases of Livestock Research Unit, USDA Agricultural Research Service, National Animal Disease Center, Ames, Iowa 50010
R. A Kunkle - Respiratory Diseases of Livestock Research Unit, USDA Agricultural Research Service, National Animal Disease Center, Ames, Iowa 50010
P. B McCray - Respiratory Diseases of Livestock Research Unit, USDA Agricultural Research Service, National Animal Disease Center, Ames, Iowa 50010
B. F Tack - Respiratory Diseases of Livestock Research Unit, USDA Agricultural Research Service, National Animal Disease Center, Ames, Iowa 50010
K. A Brogden - Respiratory Diseases of Livestock Research Unit, USDA Agricultural Research Service, National Animal Disease Center, Ames, Iowa 50010
Resource Type: Journal article
Publication Details: Antimicrobial agents and chemotherapy, Vol.45(11), pp.3256-3261
Series: Note
DOI: 10.1128/AAC.45.11.3256-3261.2001
PMID: 11600395
PMCID: PMC90821
NLM abbreviation: Antimicrob Agents Chemother
ISSN: 0066-4804
eISSN: 1098-6596
Publisher: American Society for Microbiology
Language: English
Date published: 11/2001
Academic Unit: Microbiology and Immunology; Pulmonary Medicine; Stead Family Department of Pediatrics; Periodontics; Internal Medicine
Record Identifier: 9984093507702771

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