Congenital Cytomegalovirus Infection in Pediatric Hearing Loss

Stephanie Misono; Kathleen C. Y. Sie; Noel S. Weiss; Meei-li Huang; Michael Boeckh; Susan J. Norton; Bevan Yueh

doi:10.1001/archoto.2010.235

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Congenital Cytomegalovirus Infection in Pediatric Hearing Loss

Journal article

Open access

Peer reviewed

Congenital Cytomegalovirus Infection in Pediatric Hearing Loss

Stephanie Misono, Kathleen C. Y. Sie, Noel S. Weiss, Meei-li Huang, Michael Boeckh, Susan J. Norton and Bevan Yueh

Archives of otolaryngology--head & neck surgery, Vol.137(1), pp.47-53

01/01/2011

DOI: 10.1001/archoto.2010.235

PMCID: PMC3164953

PMID: 21242546

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Abstract

Objectives: To compare the prevalence of congenital cytomegalovirus (CMV) infection in Washington State in children with hearing loss (HL) and the general population and to compare the characteristics of HL in children with and without congenital CMV infection. Design: Matched case-control; case cohort. Setting: Regional pediatric hospital, Washington State Department of Health (WSDOH). Patients: Cases were children 4 years and older with HL born in Washington State. Control individuals matched for demographic characteristics were identified at random through the WSDOH. Main Outcome Measures: Congenital CMV status determined using quantitative polymerase chain reaction testing on newborn heel stick blood spots archived by the WSDOH. Audiologic data were used to characterize HL. Results: Congenital CMV testing was performed for 222 matched cases and controls. Congenital CMV infection was detected in 1.4% of controls and in 9.9% of cases (odds ratio, 10.5; 95% confidence interval, 2.6-92.4). An estimated 8.9% of HL in children in Washington can be attributed to CMV infection. After inclusion of an additional 132 children with HL (for a total of 354 cases in the case cohort), we observed that children with congenital CMV had more severe HL (P<.001) and higher proportions of progressive (P=.02) and unilateral (P=.002) HL compared with children without congenital CMV infection. In the 35 children with congenital CMV infection, there was no relationship between neonatal CMV load and severity of HL. Conclusions: In Washington State, children with HL had a far higher prevalence of congenital CMV viremia than did the general pediatric population, and CMV infection seems to be responsible for an appreciable fraction of pediatric HL in Washington State.

Life Sciences & Biomedicine

Otorhinolaryngology

Science & Technology

Surgery

Details

Title: Subtitle: Congenital Cytomegalovirus Infection in Pediatric Hearing Loss
Creators: Stephanie Misono - University of Washington
Kathleen C. Y. Sie - University of Washington
Noel S. Weiss - University of Washington
Meei-li Huang - University of Washington
Michael Boeckh - University of Washington
Susan J. Norton - Seattle Children's Hospital
Bevan Yueh - University of Minnesota
Resource Type: Journal article
Publication Details: Archives of otolaryngology--head & neck surgery, Vol.137(1), pp.47-53
DOI: 10.1001/archoto.2010.235
PMID: 21242546
PMCID: PMC3164953
NLM abbreviation: Arch Otolaryngol Head Neck Surg
ISSN: 0886-4470
eISSN: 1538-361X
Publisher: American Medical Association
Number of pages: 7
Grant note: Viropharma Inc Chimerix Inc Gustavus and Louise Pfeiffer Research Foundation K24HL093294 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) K24 HL93294 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Theraclone Sciences Vical Inc Roche; Roche Holding
Language: English
Date published: 01/01/2011
Academic Unit: Otolaryngology
Record Identifier: 9984966850402771

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