Journal article
Congenital extrahepatic portosystemic shunt complicated by the development of hepatocellular carcinoma
Hepatobiliary & pancreatic diseases international, Vol.14(5), pp.552-557
10/01/2015
DOI: 10.1016/S1499-3872(15)60418-0
PMID: 26459734
Abstract
Congenital extrahepatic portosystemic shunt, also known as Abernethy malformation, is a rare congenital malformation. It causes shunting of blood through a communication between the portal and systemic veins such as a patent ductus venous. We report 3 cases of Abernethy malformation complicated by the development of hepatocellular carcinoma. Additionally, we comprehensively reviewed all previously reported cases and highlighted common features that may help in early diagnosis and appropriate management. Patients with Abernethy malformation may have an increased propensity to develop hepatocellular carcinoma. All 5 previously reported cases, plus the three of our patients, have a type 1 (complete) shunt suggesting a role for absent portal blood flow in the pathogenesis of hepatocellular carcinoma. Congenital extrahepatic portosystemic shunt should be sought for in cases with raised serum ammonia, hepatic encephalopathy or hepatocellular carcinoma in the absence of cirrhosis.
Details
- Title: Subtitle
- Congenital extrahepatic portosystemic shunt complicated by the development of hepatocellular carcinoma
- Creators
- Ruchi Sharma - Foundation for Liver ResearchAbid Suddle - Foundation for Liver ResearchAlberto Quaglia - Foundation for Liver ResearchPraveen Peddu - Department of Radiology, London, United KingdomJohn Karani - Department of Radiology, London, United KingdomThomas Satyadas - Manchester Royal InfirmaryNigel Heaton - Foundation for Liver Research
- Resource Type
- Journal article
- Publication Details
- Hepatobiliary & pancreatic diseases international, Vol.14(5), pp.552-557
- Publisher
- Elsevier B.V
- DOI
- 10.1016/S1499-3872(15)60418-0
- PMID
- 26459734
- ISSN
- 1499-3872
- eISSN
- 2352-9377
- Language
- English
- Date published
- 10/01/2015
- Academic Unit
- General Internal Medicine; Internal Medicine
- Record Identifier
- 9984691557702771
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