Congenital heart defects after maternal fever

Lorenzo D Botto; Janice D Panichello; Marilyn L Browne; Sergey Krikov; Marcia L Feldkamp; Edward Lammer; Gary M Shaw; National Birth Defects Prevention Study

doi:10.1016/j.ajog.2013.10.880

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Congenital heart defects after maternal fever

Journal article

Peer reviewed

Congenital heart defects after maternal fever

Lorenzo D Botto, Janice D Panichello, Marilyn L Browne, Sergey Krikov, Marcia L Feldkamp, Edward Lammer, Gary M Shaw and National Birth Defects Prevention Study

American journal of obstetrics and gynecology, Vol.210(4), pp.359.e1-359.e11

04/2014

DOI: 10.1016/j.ajog.2013.10.880

PMID: 24184180

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Abstract

The purpose of this study was to evaluate whether maternal febrile illnesses in early pregnancy are associated with increased risk for congenital heart defects in the offspring and whether such risk is mitigated by multivitamin supplement use. From a multistate population-based case-control study (National Birth Defects Prevention Study), we compared maternal reports of first-trimester febrile illness from 7020 subjects with heart defects and 6746 unaffected control subjects who were born from 1997 through 2005. Relative risks were computed with no fever or infection during the first trimester as reference group and were adjusted for potential confounders. First-trimester febrile illness was reported by 7.4% of control mothers (1 in 13). Febrile genitourinary infections were associated with selected heart defects, particularly right-sided obstructive defects (odds ratios, >3) and possibly others, whereas common respiratory illnesses were associated with low-to-negligible risks for most heart defects. When risk estimates were elevated, they tended to be mitigated when multivitamin supplements had been taken in the periconceptional period. The source of fever and the use of supplements appear to influence the risk for heart defects. This information can be helpful in counseling and research, in particular with regard to primary prevention.

Pregnancy

Antipyretics - therapeutic use

Case-Control Studies

Female

Fever - drug therapy

Fever - epidemiology

Heart Defects, Congenital - epidemiology

Humans

Infant, Newborn

Pelvic Inflammatory Disease - epidemiology

Pregnancy Complications - drug therapy

Pregnancy Complications - epidemiology

Respiratory Tract Infections - epidemiology

Risk Assessment

United States - epidemiology

Urinary Tract Infections - epidemiology

Vitamins - therapeutic use

Details

Title: Subtitle: Congenital heart defects after maternal fever
Creators: Lorenzo D Botto - Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT. Electronic address: lorenzo.botto@hsc.utah.edu
Janice D Panichello - Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT
Marilyn L Browne - Bureau of Environmental and Occupational Epidemiology, New York State Department of Health, Albany, NY
Sergey Krikov - Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT
Marcia L Feldkamp - Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT
Edward Lammer - Children's Hospital Oakland Research Institute, Oakland Children's Hospital, Oakland, CA
Gary M Shaw - Department of Pediatrics, Stanford University School of Medicine, Stanford, CA
National Birth Defects Prevention Study
Contributors: Paul A Romitti (Contributor) - University of Iowa, Epidemiology
Resource Type: Journal article
Publication Details: American journal of obstetrics and gynecology, Vol.210(4), pp.359.e1-359.e11
DOI: 10.1016/j.ajog.2013.10.880
PMID: 24184180
NLM abbreviation: Am J Obstet Gynecol
ISSN: 0002-9378
eISSN: 1097-6868
Language: English
Date published: 04/2014
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9984214789702771

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