Journal article
Congenital infantile fibrosarcoma: Association with bleeding diathesis
The American journal of case reports, Vol.14, pp.481-485
01/01/2013
DOI: 10.12659/AJCR.889489
PMCID: PMC3835170
PMID: 24265847
Abstract
Objective: Diagnostic/therapeutic accidents
Background: Congenital infantile fibrosarcoma (CIF) is a soft-tissue tumor occurring during the first 2 years of life, most commonly in the extremities. CIF is frequently initially misdiagnosed as a vascular tumor, but its association with bleeding and coagulopathy has not been well characterized.
Case Reports: We describe 2 infants with CIF presenting with bleeding and coagulopathy, requiring urgent intervention. Both patients did well; one underwent partial resection followed by chemotherapy, and the other received 2 cycles of chemotherapy followed by gross total resection. We also provide a review of all reported cases of coagulopathy in the setting of CIF in the English literature, uncovering an association that seems to be more prevalent in patients diagnosed in the neonatal period, with associated anemia and thrombocytopenia, and a significant mortality rate.
Conclusions: CIF needs to be considered in the differential diagnosis of vascular congenital tumors, especially when there is evidence of bleeding, anemia, or thrombocytopenia.
Details
- Title: Subtitle
- Congenital infantile fibrosarcoma: Association with bleeding diathesis
- Creators
- Mayssaa Salman - Amer Univ Beirut, Dept Pediat & Adolescent Med, Beirut, LebanonNabil J. Khoury - Amer Univ Beirut, Dept Diagnost Radiol, Beirut, LebanonIbrahim Khalifeh - Amer Univ Beirut, Dept Pathol & Lab Med, Beirut, LebanonHussein A. Abbas - Amer Univ Beirut, Dept Pediat & Adolescent Med, Beirut, LebanonMarianne Majdalani - Amer Univ Beirut, Dept Pediat & Adolescent Med, Beirut, LebanonMiguel Abboud - Amer Univ Beirut, Dept Pediat & Adolescent Med, Beirut, LebanonSamar Muwakkit - Amer Univ Beirut, Dept Pediat & Adolescent Med, Beirut, LebanonHassan El Solh - Amer Univ Beirut, Dept Pediat & Adolescent Med, Beirut, LebanonRaya Saab - American University of Beirut
- Resource Type
- Journal article
- Publication Details
- The American journal of case reports, Vol.14, pp.481-485
- Publisher
- INT SCIENTIFIC LITERATURE, INC
- DOI
- 10.12659/AJCR.889489
- PMID
- 24265847
- PMCID
- PMC3835170
- ISSN
- 1941-5923
- eISSN
- 1941-5923
- Number of pages
- 5
- Language
- English
- Date published
- 01/01/2013
- Academic Unit
- Radiology
- Record Identifier
- 9984697634102771
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