Journal article
Congenital lymphocytic choriomeningitis virus infection : Spectrum of disease
Annals of neurology, Vol.62(4), pp.347-355
2007
DOI: 10.1002/ana.21161
PMID: 17557350
Abstract
Objective: Lymphocytic choriomeningitis virus (LCMV) is a human pathogen and an emerging neuroteratogen. When the infection occurs during pregnancy, the virus can target and damage the fetal brain and retina. We examined the spectrum of clinical presentations, neuroimaging findings, and clinical outcomes of children with congenital LCMV infection.
Methods: Twenty children with serologically confirmed congenital LCMV infection were identified. The children underwent neuroimaging studies and were followed prospectively for up to 11 years.
Results: All children with congenital LCMV infection had chorioretinitis and structural brain anomalies. However, the presenting clinical signs, severity of vision disturbance, nature and location of neuropathology, and character and severity of brain dysfunction varied substantially among cases. Neuroimaging abnormalities included microencephaly, periventricular calcifications, ventriculomegaly, pachygyria, cerebellar hypoplasia, porencephalic cysts, periventricular cysts, and hydrocephalus. The combination of microencephaly and periventricular calcifications was the most common neuroimaging abnormality, and all children with this combination had profound mental retardation, epilepsy, and cerebral palsy. However, others had less severe neuroimaging abnormalities and better outcomes. Some children had isolated cerebellar hypoplasia, with jitteriness as their presenting sign and ataxia as their principal long-term neurological dysfunction.
Interpretation: Congenital LCMV infection can have diverse presenting signs, neuroimaging abnormalities, and clinical outcomes. In the companion article to this study, we utilize an animal model to show that the clinical and pathological diversity in congenital LCMV infection is likely due to differences in the gestational timing of infection.
Details
- Title: Subtitle
- Congenital lymphocytic choriomeningitis virus infection : Spectrum of disease
- Creators
- Daniel J BONTHIUS - Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA, United StatesRhonda WRIGHT - Department of Pediatric Neurology, University of Nebraska College of Medicine, Omaha, NE, United StatesBrian TSENG - Departments of Pe diatrics and Neurology, University of Colorado Health Sciences Center at Fitzsimons, The Children's Hospital, Aurora, CO, United StatesLeslie BARTON - Department of Pediatrics, University of Arizona, Tucson, AZ, United StatesElysa MARCO - Department of Pediatrics, University of California San Francisco, San Francisco, CA, United StatesBahri KARACAY - Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA, United StatesPaul D LARSEN - Department of Pediatric Neurology, University of Nebraska College of Medicine, Omaha, NE, United States
- Resource Type
- Journal article
- Publication Details
- Annals of neurology, Vol.62(4), pp.347-355
- Publisher
- Willey-Liss; Hoboken
- DOI
- 10.1002/ana.21161
- PMID
- 17557350
- ISSN
- 0364-5134
- eISSN
- 1531-8249
- Language
- English
- Date published
- 2007
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984065735702771
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