Journal article
Connections matter - how viruses use cell-cell adhesion components
Journal of cell science, Vol.128(3), pp.431-439
02/01/2015
DOI: 10.1242/jcs.159400
PMCID: PMC4311127
PMID: 26046138
Abstract
The epithelium is a highly organized type of animal tissue. Except for blood and lymph vessels, epithelial cells cover the body, line its cavities in single or stratified layers and support exchange between compartments. In addition, epithelia offer to the body a barrier to pathogen invasion. To transit through or to replicate in epithelia, viruses have to face several obstacles, starting from cilia and glycocalyx where they can be neutralized by secreted immunoglobulins. Tight junctions and adherens junctions also prevent viruses to cross the epithelial barrier. However, viruses have developed multiple strategies to blaze their path through the epithelium by utilizing components of cell-cell adhesion structures as receptors. In this Commentary, we discuss how viruses take advantage of the apical junction complex to spread. Whereas some viruses quickly disrupt epithelium integrity, others carefully preserve it and use cell adhesion proteins and their cytoskeletal connections to rapidly spread laterally. This is exemplified by the hidden transmission of enveloped viruses that use nectins as receptors. Finally, several viruses that replicate preferentially in cancer cells are currently used as experimental cancer therapeutics. Remarkably, these viruses use cell adhesion molecules as receptors, probably because - to reach tumors and metastases - oncolytic viruses must efficiently traverse or break epithelia.
Details
- Title: Subtitle
- Connections matter - how viruses use cell-cell adhesion components
- Creators
- Mathieu Mateo - Mayo Clinic in ArizonaAlex Generous - Gene Therapy LaboratoryPatrick L. Sinn - University of IowaRoberto Cattaneo - Gene Therapy Laboratory
- Resource Type
- Journal article
- Publication Details
- Journal of cell science, Vol.128(3), pp.431-439
- Publisher
- Company Biologists Ltd
- DOI
- 10.1242/jcs.159400
- PMID
- 26046138
- PMCID
- PMC4311127
- ISSN
- 0021-9533
- eISSN
- 1477-9137
- Number of pages
- 9
- Grant note
- R01 AI063476; CA139398 / National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R15CA139398 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R01AI063476 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) Mayo Graduate School
- Language
- English
- Date published
- 02/01/2015
- Academic Unit
- Microbiology and Immunology; Pulmonary Medicine; Stead Family Department of Pediatrics
- Record Identifier
- 9984297428702771
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