Journal article
Connectivity of sleep- and wake-promoting regions of the human hypothalamus observed during resting wakefulness
Sleep (New York, N.Y.), Vol.41(9), p.1
09/01/2018
DOI: 10.1093/sleep/zsy108
PMCID: PMC6454456
PMID: 29850898
Abstract
The hypothalamus is a central hub for regulating sleep-wake patterns, the circuitry of which has been investigated extensively in experimental animals. This work has identified a wake-promoting region in the posterior hypothalamus, with connections to other wake-promoting regions, and a sleep-promoting region in the anterior hypothalamus, with inhibitory projections to the posterior hypothalamus. It is unclear whether a similar organization exists in humans. Here, we use anatomical landmarks to identify homologous sleep- and wake-promoting regions of the human hypothalamus and investigate their functional relationships using resting-state functional connectivity magnetic resonance imaging in healthy awake participants. First, we identify a negative correlation (anticorrelation) between the anterior and posterior hypothalamus, two regions with opposing roles in sleep-wake regulation. Next, we show that hypothalamic connectivity predicts a pattern of regional sleep-wake changes previously observed in humans. Specifically, regions that are more positively correlated with the posterior hypothalamus and more negatively correlated with the anterior hypothalamus correspond to regions with the greatest change in cerebral blood flow between sleep-wake states. Taken together, these findings provide preliminary evidence relating a hypothalamic circuit investigated in animals to sleep-wake neuroimaging results in humans, with implications for our understanding of human sleep-wake regulation and the functional significance of anticorrelations.
Details
- Title: Subtitle
- Connectivity of sleep- and wake-promoting regions of the human hypothalamus observed during resting wakefulness
- Creators
- Aaron D Boes - Department of Psychiatry, Iowa Neuroimaging and Noninvasive Brain Stimulation Program, University of Iowa Hospitals and Clinics, Iowa City, IADavid Fischer - Department of Neurology, Berenson-Allen Center for Noninvasive Brain Stimulation, Division of Cognitive Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MAJoel C Geerling - Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, IAJoel Bruss - Department of Neurology, Iowa Neuroimaging and Noninvasive Brain Stimulation Program, University of Iowa Hospitals and Clinics, Iowa City, IAClifford B Saper - Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MAMichael D Fox - Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
- Resource Type
- Journal article
- Publication Details
- Sleep (New York, N.Y.), Vol.41(9), p.1
- Publisher
- United States
- DOI
- 10.1093/sleep/zsy108
- PMID
- 29850898
- PMCID
- PMC6454456
- ISSN
- 0161-8105
- eISSN
- 1550-9109
- Grant note
- T32 HL007901 / NHLBI NIH HHS Howard Hughes Medical Institute R01 MH113929 / National Institute of Mental Health P01 HL095491 / NHLBI NIH HHS K08 NS099425 / NINDS NIH HHS R01 NS085477 / NINDS NIH HHS K12 NS098482 / NINDS NIH HHS K12 HD027748 / NICHD NIH HHS R25 NS070682 / NINDS NIH HHS K23 NS083741 / NINDS NIH HHS
- Language
- English
- Date published
- 09/01/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984020503802771
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