Consanguinity: A Risk Factor for Preterm Birth at Less Than 33 Weeks' Gestation

Ghina MUMTAZ; Anwar H NASSAR; Ziyad MAHFOUD; Akaber EL-KHAMRA; Nathalie AL-CHOUEIRI; Abdallah ADRA; Jeffrey C MURRAY; Pierre ZALLOUA; Khalid A YUNIS

doi:10.1093/aje/kwq316

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Consanguinity: A Risk Factor for Preterm Birth at Less Than 33 Weeks' Gestation

Journal article

Open access

Peer reviewed

Consanguinity: A Risk Factor for Preterm Birth at Less Than 33 Weeks' Gestation

Ghina MUMTAZ, Anwar H NASSAR, Ziyad MAHFOUD, Akaber EL-KHAMRA, Nathalie AL-CHOUEIRI, Abdallah ADRA, Jeffrey C MURRAY, Pierre ZALLOUA and Khalid A YUNIS

American journal of epidemiology, Vol.172(12), pp.1424-1430

2010

DOI: 10.1093/aje/kwq316

PMCID: PMC2998204

PMID: 20978088

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Abstract

Consanguinity promotes homozygosity of recessive susceptibility gene variants and can be used to investigate a recessive component in diseases whose inheritance is uncertain. The objective of this study was to assess the association between consanguinity and preterm birth (PTB), stratified by gestational age and clinical presentation (spontaneous vs. medically indicated). Data were collected on 39,745 singleton livebirths without major birth defects, admitted to 19 hospitals in Lebanon, from September 2003 to December 2007. Deliveries before completed 33 weeks' gestation and deliveries at 33-36 weeks' gestation were compared, with respect to cousin marriage, with those after completed 36 weeks' gestation by using multinomial multiple logistic regression. Overall, infants of consanguineous parents had a statistically significant 1.6-fold net increased risk of being born at less than 33 weeks' gestation compared with infants of unrelated parents. This association was statistically significant only with spontaneous PTB. There was no increased risk of being born at 33-36 weeks' gestation associated with consanguinity for both clinical presentations of PTB. Our findings support a genetic contribution to early onset PTB and suggest that early PTB should be targeted in future genetic studies rather than the classic lumping of all births less than 37 weeks' gestation.

Epidemiology

Gynecology. Andrology. Obstetrics

Public health. Hygiene-occupational medicine

Public health. Hygiene

General aspects

Miscellaneous

Diseases of mother, fetus and pregnancy

Biological and medical sciences

Pregnancy. Fetus. Placenta

Medical sciences

Details

Title: Subtitle: Consanguinity: A Risk Factor for Preterm Birth at Less Than 33 Weeks' Gestation
Creators: Ghina MUMTAZ - Department of Pediatrics, American University of Beirut Medical Center, Beirut, Lebanon
Anwar H NASSAR - Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon
Ziyad MAHFOUD - Infectious Disease Epidemiology Group, Weill Cornell Medical College—Qatar, Cornell University, Qatar Foundation—Education City, Doha, Qatar
Akaber EL-KHAMRA - Department of Pediatrics, American University of Beirut Medical Center, Beirut, Lebanon
Nathalie AL-CHOUEIRI - Department of Pediatrics, American University of Beirut Medical Center, Beirut, Lebanon
Abdallah ADRA - Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon
Jeffrey C MURRAY - Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States
Pierre ZALLOUA - School of Medicine, Lebanese American University, Byblos, Lebanon
Khalid A YUNIS - Department of Pediatrics, American University of Beirut Medical Center, Beirut, Lebanon
Resource Type: Journal article
Publication Details: American journal of epidemiology, Vol.172(12), pp.1424-1430
DOI: 10.1093/aje/kwq316
PMID: 20978088
PMCID: PMC2998204
NLM abbreviation: Am J Epidemiol
ISSN: 0002-9262
eISSN: 1476-6256
Publisher: Oxford University Press; Cary, NC
Language: English
Date published: 2010
Academic Unit: Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
Record Identifier: 9984025459502771

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