Journal article
Consanguinity, endogamy, and genetic disorders in Tunisia
Journal of community genetics, Vol.4(2), pp.273-284
04/01/2013
DOI: 10.1007/s12687-012-0128-7
PMCID: PMC3666836
PMID: 23208456
Abstract
Consanguinity refers to marriages between individuals who share at least one common ancestor. In clinical genetics, a consanguineous marriage is defined as a union between two individuals who are related as second cousins or closer, with the inbreeding coefficient (F) equal or higher than 0.0156 (Bittles2001). However, reports on consanguinity rates may sometimes include marriages between third cousins or more distantly related individuals (Hamamy2011). It is estimate that more than 690 million people in the world are consan- guineous (Bittles and Black 2010 ). Middle East, Northern Africa, and South Asia are regions that have historically and culturally had a high rate of consanguineous unions (Al- Awadi et al. 1985; Al-Gazali et al.1997; Jaber et al.1997;Bittles et al.2002; Bener and Alali2006). Recent studieshave shown that 20 % to 50 % of marriages in Arab countries are between relatives (Tadmouri et al. 2009;Bittles2011; Hamamy et al.2011). The rate was 68 % inEgypt (Mokhtar and Abdel-Fattah2001), 51-58 % in Jordan
Details
- Title: Subtitle
- Consanguinity, endogamy, and genetic disorders in Tunisia
- Creators
- Nizar Ben Halim - Institut Pasteur de TunisNissaf Ben Alaya Bouafif - Institut Pasteur de TunisLilia Romdhane - Institut Pasteur de TunisRym Kefi Ben Atig - Institut Pasteur de TunisIbtissem Chouchane - Institute of OphthalmologyYosra Bouyacoub - Institut Pasteur de TunisImen Arfa - Institut Pasteur de TunisWafa Cherif - Institut Pasteur de TunisSonia Nouira - Institut Pasteur de TunisFaten Talmoudi - Institut Pasteur de TunisKhaled Lasram - Institut Pasteur de TunisSana Hsouna - Institut Pasteur de TunisWelid Ghazouani - Institut Pasteur de TunisHela Azaiez - Institut Pasteur de TunisLeila El Matri - Institute of OphthalmologyAbdelmajid Abid - Institut Pasteur de TunisNeji Tebib - Hôpital La RabtaMarie-Françoise Ben Dridi - Hôpital La RabtaSalem Kachboura - Abderrahmane Mami HospitalAhlem Amouri - Institut Pasteur de TunisMourad Mokni - Hôpital La RabtaSaida Ben ArabKoussay Dellagi - Institut Pasteur de TunisSonia Abdelhak - Institut Pasteur de Tunis
- Resource Type
- Journal article
- Publication Details
- Journal of community genetics, Vol.4(2), pp.273-284
- DOI
- 10.1007/s12687-012-0128-7
- PMID
- 23208456
- PMCID
- PMC3666836
- NLM abbreviation
- J Community Genet
- ISSN
- 1868-310X
- eISSN
- 1868-6001
- Publisher
- Springer
- Language
- English
- Date published
- 04/01/2013
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984383907602771
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