Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

Colleen M McDowell; Krishnakumar Kizhatil; Michael H Elliott; Darryl R Overby; Joseph van Batenburg-Sherwood; J Cameron Millar; Markus H Kuehn; Gulab Zode; Ted S Acott; Michael G Anderson; Sanjoy K Bhattacharya; Jacques A Bertrand; Terete Borras; Diane E Bovenkamp; Lin Cheng; John Danias; Michael Lucio De Ieso; Yiqin Du; Jennifer A Faralli; Rudolf Fuchshofer; Preethi S Ganapathy; Haiyan Gong; Samuel Herberg; Humberto Hernandez; Peter Humphries; Simon W M John; Paul L Kaufman; Kate E Keller; Mary J Kelley; Ruth A Kelly; David Krizaj; Ajay Kumar; Brian C Leonard; Raquel L Lieberman; Paloma Liton; Yutao Liu; Katy C Liu; Navita N Lopez; Weiming Mao; Timur Mavlyutov; Fiona McDonnell; Gillian J McLellan; Philip Mzyk; Andrews Nartey; Louis R Pasquale; Gaurang C Patel; Padmanabhan P Pattabiraman; Donna M Peters; Vijaykrishna Raghunathan; Ponugoti Vasantha Rao; Naga Rayana; Urmimala Raychaudhuri; Ester Reina-Torres; Ruiyi Ren; Douglas Rhee; Uttio Roy Chowdhury; John R Samples; E Griffen Samples; Najam Sharif; Joel S Schuman; Val C Sheffield; Cooper H Stevenson; Avinash Soundararajan; Preeti Subramanian; Chenna Kesavulu Sugali; Yang Sun; Carol B Toris; Karen Y Torrejon; Amir Vahabikashi; Janice A Vranka; Ting Wang; Colin E Willoughby; Chen Xin; Hongmin Yun; Hao F Zhang; Michael P Fautsch; Ernst R Tamm; Abbot F Clark; C Ross Ethier; W Daniel Stamer

doi:10.1167/iovs.63.2.12

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Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

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Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

Colleen M McDowell, Krishnakumar Kizhatil, Michael H Elliott, Darryl R Overby, Joseph van Batenburg-Sherwood, J Cameron Millar, Markus H Kuehn, Gulab Zode, Ted S Acott, Michael G Anderson, …

Investigative ophthalmology & visual science, Vol.63(2), pp.12-12

02/01/2022

DOI: 10.1167/iovs.63.2.12

PMCID: PMC8842499

PMID: 35129590

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Abstract

Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.

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Title: Subtitle: Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms
Creators: Colleen M McDowell - Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States
Krishnakumar Kizhatil - The Jackson Laboratory, Bar Harbor, Maine, United States
Michael H Elliott - University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
Darryl R Overby - Department of Bioengineering, Imperial College London, United Kingdom
Joseph van Batenburg-Sherwood - Department of Bioengineering, Imperial College London, United Kingdom
J Cameron Millar - Department of Pharmacology & Neuroscience, and North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, Texas, United States
Markus H Kuehn - Department of Ophthalmology and Visual Sciences and Institute for Vision Research, The University of Iowa; Center for the Prevention and Treatment of Visual Loss, Veterans Affairs Medical Center, Iowa City, Iowa, United States
Gulab Zode - Department of Pharmacology & Neuroscience, and North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, Texas, United States
Ted S Acott - Ophthalmology and Biochemistry and Molecular Biology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
Michael G Anderson - Department of Molecular Physiology and Biophysics and Department of Ophthalmology and Visual Sciences, The University of Iowa; Center for the Prevention and Treatment of Visual Loss, Veterans Affairs Medical Center, Iowa City, Iowa, United States
Sanjoy K Bhattacharya - Bascom Palmer Eye Institute, University of Miami, Miami, Florida, United States
Jacques A Bertrand - Department of Bioengineering, Imperial College London, London, United Kingdom
Terete Borras - University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
Diane E Bovenkamp - Brightfocus Foundation, Clarksburg, Maryland, United States
Lin Cheng - Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States
John Danias - SUNY Downstate Health Sciences University, Brooklyn, New York, United States
Michael Lucio De Ieso - Department of Ophthalmology, Duke Eye Center, Duke University, Durham, North Carolina, United States
Yiqin Du - Department of Ophthalmology, University of Pittsburgh, Pennsylvania, United States
Jennifer A Faralli - Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States
Rudolf Fuchshofer - Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany
Preethi S Ganapathy - Department of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, New York, United States
Haiyan Gong - Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States
Samuel Herberg - Department of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, New York, United States
Humberto Hernandez - University of Houston-Victoria, Victoria, Texas, United States
Peter Humphries - Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland
Simon W M John - Department of Ophthalmology, Columbia University, New York, New York, United States
Paul L Kaufman - Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States
Kate E Keller - Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
Mary J Kelley - Department of Ophthalmology and Department of Integrative Biosciences, Oregon Health & Science University, Portland, Oregon, United States
Ruth A Kelly - Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland
David Krizaj - Department of Ophthalmology, University of Utah School of Medicine, Salt Lake City, Utah, United States
Ajay Kumar - Department of Ophthalmology, University of Pittsburgh, Pennsylvania, United States
Brian C Leonard - Department of Surgical and Radiological Sciences, University of California, Davis, Davis, California, United States
Raquel L Lieberman - Department of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, United States
Paloma Liton - Department of Ophthalmology and Department of Pathology, Duke University, Durham, North Carolina, United States
Yutao Liu - Department of Cellular Biology and Anatomy, James & Jean Culver Vision Discovery Institute, Augusta University, Augusta, Georgia, United States
Katy C Liu - Duke Eye Center, Duke Health, Durham, North Carolina, United States
Navita N Lopez - Department of Neurobiology, University of Utah, Salt Lake City, Utah, United States
Weiming Mao - Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
Timur Mavlyutov - Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States
Fiona McDonnell - Duke Eye Center, Duke Health, Durham, North Carolina, United States
Gillian J McLellan - Department of Surgical Sciences and Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States
Philip Mzyk - Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States
Andrews Nartey - College of Optometry, University of Houston, Houston, Texas, United States
Louis R Pasquale - Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
Gaurang C Patel - Ophthalmology Research, Regeneron Pharmaceuticals, Tarreytown, New York, United States
Padmanabhan P Pattabiraman - Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
Donna M Peters - Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States
Vijaykrishna Raghunathan - College of Optometry, University of Houston, Houston, Texas, United States
Ponugoti Vasantha Rao - Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, United States
Naga Rayana - Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
Urmimala Raychaudhuri - Department of Neurobiology, University of California, Irvine, Irvine, California, United States
Ester Reina-Torres - Department of Bioengineering, Imperial College London, London, United Kingdom
Ruiyi Ren - Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States
Douglas Rhee - Case Western Reserve University School of Medicine, Cleveland, Ohio, United States
Uttio Roy Chowdhury - Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, United States
John R Samples - Washington State University, Floyd Elson College of Medicine, Spokane, Washington, United States
E Griffen Samples - Western Glaucoma Foundation, Sisters, Oregon, United States
Najam Sharif - Santen Inc., Emeryville, California, United States
Joel S Schuman - Department of Ophthalmology and Department of Physiology and Neuroscience, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, New York, United States; Departments of Biomedical Engineering and Electrical and Computer Engineering, New York University Tandon School of Engineering, Brooklyn, New York, United States; Center for Neural Science, College of Arts and Science, New York University, New York, New York, United States
Val C Sheffield - Department of Pediatrics and Department of Ophthalmology and Visual Sciences, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States
Cooper H Stevenson - Department of Pharmacology & Neuroscience, and North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, Texas, United States
Avinash Soundararajan - Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
Preeti Subramanian - Brightfocus Foundation, Clarksburg, Maryland, United States
Chenna Kesavulu Sugali - Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
Yang Sun - Veterans Affairs Palo Alto Health Care System, Stanford University, Palo Alto, California, United States
Carol B Toris - Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States; Department of Ophthalmology and Vision Sciences, The Ohio State University, Columbus, Ohio, United States
Karen Y Torrejon - Glauconix Biosciences, Albany, New York, United States
Amir Vahabikashi - Cell and Developmental Biology Department, Northwestern University, Chicago, Illinois, United States
Janice A Vranka - Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
Ting Wang - Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
Colin E Willoughby - Genomic Medicine, Biomedical Sciences Research Institute, Ulster University, Coleraine, Northern Ireland, United Kingdom
Chen Xin - Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China
Hongmin Yun - Department of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States
Hao F Zhang - Biomedical Engineering Department, Northwestern University, Evanston, Illinois, United States
Michael P Fautsch - Biomedical Engineering Department, Northwestern University, Evanston, Illinois, United States
Ernst R Tamm - University of Regensburg, Regensburg, Germany
Abbot F Clark - Department of Pharmacology and Neuroscience, North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, Texas, United States
C Ross Ethier - Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology; Emory University School of Medicine, Emory University, Atlanta, Georgia, United States
W Daniel Stamer - Duke Ophthalmology, Duke University, Durham, North Carolina, United States
Resource Type: Journal article
Publication Details: Investigative ophthalmology & visual science, Vol.63(2), pp.12-12
DOI: 10.1167/iovs.63.2.12
PMID: 35129590
PMCID: PMC8842499
ISSN: 0146-0404
eISSN: 1552-5783
Language: English
Date published: 02/01/2022
Academic Unit: Molecular Physiology and Biophysics; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Medical Genetics and Genomics; Ophthalmology and Visual Sciences
Record Identifier: 9984215160102771

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