Journal article
Consensus Statement of the Malignant Hyperthermia Association of the United States on Unresolved Clinical Questions Concerning the Management of Patients With Malignant Hyperthermia
Anesthesia and analgesia, Vol.128(4), pp.652-659
04/2019
DOI: 10.1213/ane.0000000000004039
PMID: 30768455
Abstract
At a recent consensus conference, the Malignant Hyperthermia Association of the United States addressed 6 important and unresolved clinical questions concerning the optimal management of patients with malignant hyperthermia (MH) susceptibility or acute MH. They include: (1) How much dantrolene should be available in facilities where volatile agents are not available or administered, and succinylcholine is only stocked on site for emergency purposes? (2) What defines masseter muscle rigidity? What is its relationship to MH, and how should it be managed when it occurs? (3) What is the relationship between MH susceptibility and heat- or exercise-related rhabdomyolysis? (4) What evidence-based interventions should be recommended to alleviate hyperthermia associated with MH? (5) After treatment of acute MH, how much dantrolene should be administered and for how long? What criteria should be used to determine stopping treatment with dantrolene? (6) Can patients with a suspected personal or family history of MH be safely anesthetized before diagnostic testing? This report describes the consensus process and the outcomes for each of the foregoing unanswered clinical questions.
Details
- Title: Subtitle
- Consensus Statement of the Malignant Hyperthermia Association of the United States on Unresolved Clinical Questions Concerning the Management of Patients With Malignant Hyperthermia
- Creators
- Ronald S Litman - Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PennsylvaniaVictoria I Smith - Department of Chemistry, Drexel University, Philadelphia, PennsylvaniaMarilyn Green Larach - The North American Malignant Hyperthermia Registry of the Malignant Hyperthermia Association of the United States at the Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FloridaLena Mayes - Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, ColoradoMohanad Shukry - University of Nebraska Medical Center, Omaha, NebraskaMary C Theroux - Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PennsylvaniaStacey Watt - Department of Anesthesiology, University at Buffalo School of Medicine, Kaleida Health, Buffalo, New YorkCynthia A Wong - Department of Anesthesia, University of Iowa, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Anesthesia and analgesia, Vol.128(4), pp.652-659
- Publisher
- United States
- DOI
- 10.1213/ane.0000000000004039
- PMID
- 30768455
- ISSN
- 0003-2999
- eISSN
- 1526-7598
- Language
- English
- Date published
- 04/2019
- Academic Unit
- Anesthesia
- Record Identifier
- 9984006461302771
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