Journal article
Consensus Treatment Plans for Chronic Nonbacterial Osteomyelitis Refractory to Nonsteroidal Antiinflammatory Drugs and/or With Active Spinal Lesions
Arthritis care & research (2010), Vol.70(8), pp.1228-1237
08/2018
DOI: 10.1002/acr.23462
PMCID: PMC5938153
PMID: 29112802
Abstract
To develop standardized treatment regimens for chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis (CRMO), to enable comparative effectiveness treatment studies.
Virtual and face-to-face discussions and meetings were held within the CNO/CRMO subgroup of the Childhood Arthritis and Rheumatology Research Alliance (CARRA). A literature search was conducted, and CARRA membership was surveyed to evaluate available treatment data and identify current treatment practices. Nominal group technique was used to achieve consensus on treatment plans for CNO refractory to nonsteroidal antiinflammatory drug (NSAID) monotherapy and/or with active spinal lesions.
Three consensus treatment plans (CTPs) were developed for the first 12 months of therapy for CNO patients refractory to NSAID monotherapy and/or with active spinal lesions. The 3 CTPs are methotrexate or sulfasalazine, tumor necrosis factor inhibitors with optional methotrexate, and bisphosphonates. Short courses of glucocorticoids and continuation of NSAIDs are permitted for all regimens. Consensus was achieved on these CTPs among CARRA members. Consensus was also reached on subject eligibility criteria, initial evaluations that should be conducted prior to the initiation of CTPs, and data items to collect to assess treatment response.
Three consensus treatment plans were developed for pediatric patients with CNO refractory to NSAIDs and/or with active spinal lesions. Use of these CTPs will provide additional information on efficacy and will generate meaningful data for comparative effectiveness research in CNO.
Details
- Title: Subtitle
- Consensus Treatment Plans for Chronic Nonbacterial Osteomyelitis Refractory to Nonsteroidal Antiinflammatory Drugs and/or With Active Spinal Lesions
- Creators
- Yongdong Zhao - Seattle Children's Hospital, University of Washington, SeattlePolly J Ferguson - University of Iowa Carver College of Medicine, Iowa CityEveline Y Wu - University of North Carolina, Chapel HillMelissa S Oliver - Stanford Children's Health, Stanford University, Palo Alto, CaliforniaAshley M Cooper - Children's Mercy, Kansas City, MissouriMatthew L Basiaga - Seattle Children's Hospital, University of Washington, SeattleSheetal S Vora - Levine Children's Hospital, Charlotte, North CarolinaTzielan C Lee - Stanford Children's Health, Stanford University, Palo Alto, CaliforniaEmily Fox - Children's Mercy HospitalGil Amarilyo - Schneider Children's Medical Center of Israel, Petach Tikva Israel, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelSara M Stern - University of Utah, Salt Lake CityJeffrey A Dvergsten - Duke Children's Hospital, Durham, North CarolinaKathleen A Haines - Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack, New JerseyKelly A Rouster-Stevens - Children's Healthcare of Atlanta, Emory University, Atlanta, GeorgiaKaren B Onel - Hospital for Special Surgery, New York, New YorkJulie Cherian - Stony Brook Children's Hospital, Stony Brook, New YorkJonathan S Hausmann - Boston Children's Hospital and Beth Israel Deaconess Medical Center, Boston, MassachusettsPaivi Miettunen - University of Calgary, Calgary, Alberta, CanadaTania Cellucci - McMaster Children's Hospital, Hamilton, Ontario, CanadaAngela Taneja - Children's Healthcare of Atlanta, Emory University, Atlanta, GeorgiaFarzana Nuruzzaman - Stony Brook Children's Hospital, Stony Brook, New YorkKaryl S Barron - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MarylandMatthew C Hollander - University of Vermont Medical Center, BurlingtonSivia K Lapidus - Goryeb Children's Hospital, Morristown, New JerseySuzanne C Li - Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack, New JerseySeza Ozen - Hacettepe University, Ankara, TurkeyHermann Girschick - Vivantes Children's Hospital in Friedrichshain, Berlin, GermanyRonald M Laxer - The Hospital for Sick Children and University of Toronto, Toronto, Ontario, CanadaFatma Dedeoglu - Boston Children's Hospital, Boston, MassachusettsChristian M Hedrich - Children's Hospital Dresden, University Medical Center Carl Gustav Carus, TU Dresden, Dresden, Germany, and Institute of Translational Medicine, University of Liverpool, and Alder Hey Children's NHS Foundation Trust Hospital, Liverpool, UK
- Resource Type
- Journal article
- Publication Details
- Arthritis care & research (2010), Vol.70(8), pp.1228-1237
- DOI
- 10.1002/acr.23462
- PMID
- 29112802
- PMCID
- PMC5938153
- NLM abbreviation
- Arthritis Care Res (Hoboken)
- ISSN
- 2151-464X
- eISSN
- 2151-4658
- Publisher
- United States
- Grant note
- R01 AR059703 / NIAMS NIH HHS T32 GM075766 / NIGMS NIH HHS T32 AR050942 / NIAMS NIH HHS
- Language
- English
- Date published
- 08/2018
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Rheumatology, Allergy, and Immunology
- Record Identifier
- 9984070475902771
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