Journal article
Considerations in Using US-Based Laboratory Toxicity Tables to Evaluate Laboratory Toxicities Among Healthy Malawian and Ugandan Infants
Journal of acquired immune deficiency syndromes (1999), Vol.55(1), pp.58-64
2010
DOI: 10.1097/QAI.0b013e3181db059d
PMCID: PMC3033212
PMID: 20588184
Abstract
Objectives: To determine normal hematologic and selected blood chemistry values among healthy, full-term, non-HIV-exposed infants in Uganda and Malawi, and to determine the proportion of healthy babies with an apparent laboratory toxicity based on Division of AIDS toxicity tables.
Design: This was a cross-sectional laboratory study of infants from birth to 6 months of age.
Methods: Blood samples were collected from a total of 561 infants and analyzed according to age categories similar to those in the 2004 Division of AIDS toxicity tables. Select chemistry and hematology parameters were determined and values compared with those in the toxicity tables.
Results: In the first 56 days of life, there were few graded toxicities except for neutropenia in 2 of 10 (20%) Ugandan and 13 of 45 (29%) Malawian infants at birth. After 7 days, about 20% of the infants in Uganda and Malawi would have been classified as having a neutropenia whereas 47% and 53% of those more than 2 months of age in Uganda and Malawi respectively, would have been reported as having an abnormal hemoglobin. Chemistry findings were not different from US norms.
Conclusions: These findings underscore the importance of establishing relevant local laboratory norms for infants.
Details
- Title: Subtitle
- Considerations in Using US-Based Laboratory Toxicity Tables to Evaluate Laboratory Toxicities Among Healthy Malawian and Ugandan Infants
- Creators
- Irene R LUBEGA - Makerere University-Johns Hopkins University Research Collaboration, Kampala, UgandaMary Glenn FOWLER - Makerere University-Johns Hopkins University Research Collaboration, Kampala, UgandaTaha TAHA - Department of Epidemiology, John Hopkins Bloomberg School of Public Health, Baltimore, MD, United StatesJ. Brooks JACKSON - Department of Pathology Johns Hopkins University School of Medicine, Baltimore, MD, United StatesLaura GUAY - Department of Epidemiology/Biostatistics, George Washington University School of Public Health and Health Service, Washington, DC, United StatesPhilippa M MUSOKE - Makerere University-Johns Hopkins University Research Collaboration, Kampala, UgandaAli ELBIREER - Makerere University-Johns Hopkins University Research Collaboration, Kampala, UgandaDanstan BAGENDA - Makerere University-Johns Hopkins University Research Collaboration, Kampala, UgandaGeorge KAFULAFULA - College of Medicine, University of Malawi, Blantyre, MalawiJeanne KO - Department of Epidemiology, John Hopkins Bloomberg School of Public Health, Baltimore, MD, United StatesLinda MIPANDO - Johns Hopkins University-Malawi College of Medicine Research Project, Blantyre, MalawiMike MUBIRU - Makerere University-Johns Hopkins University Research Collaboration, Kampala, UgandaNewton KUMWENDA - Department of Epidemiology, John Hopkins Bloomberg School of Public Health, Baltimore, MD, United States
- Resource Type
- Journal article
- Publication Details
- Journal of acquired immune deficiency syndromes (1999), Vol.55(1), pp.58-64
- DOI
- 10.1097/QAI.0b013e3181db059d
- PMID
- 20588184
- PMCID
- PMC3033212
- NLM abbreviation
- J Acquir Immune Defic Syndr
- ISSN
- 1525-4135
- eISSN
- 1944-7884
- Publisher
- Lippincott Williams & Wilkins; Hagerstown, MD
- Language
- English
- Date published
- 2010
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984047636702771
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