Journal article
Consistency of knee pain and risk of knee replacement: the Multicenter Osteoarthritis Study
Journal of rheumatology, Vol.38(7), pp.1390-1395
07/2011
DOI: 10.3899/jrheum.100743
PMCID: PMC3222910
PMID: 21498481
Abstract
To examine whether the consistency or persistence of knee pain, in addition to its severity, predicts incident total knee replacement (TKR).
The Multicenter Osteoarthritis Study (MOST) is a longitudinal study of persons aged 50 to 79 years with symptomatic knee osteoarthritis or at high risk of disease. Subjects were queried about the presence of knee pain on most days of the previous 30 days (i.e., frequent knee pain; FKP) at 2 timepoints: a telephone screen followed by a clinic visit (median separation 4 weeks). We defined a knee as having "consistent pain" if the subject answered positively to the FKP question at both timepoints, "inconsistent pain" if FKP was positive at only one timepoint, or as "no FKP" if negative at both. We examined the association between consistent FKP and risk of TKR using multiple binomial regression with generalized estimating equations.
In 3026 persons (mean age 63 yrs, mean body mass index 30.4), 2979 knees (50%) had no FKP at baseline, 1279 knees (21.5%) had inconsistent FKP, and 1696 knees (28.5%) had consistent FKP. Risk of TKR over 30 months was 0.8%, 2.6%, and 8.8% for knees with no, inconsistent, and consistent FKP, respectively. Relative risks of TKR over 30 months were 1.2 (95% CI 0.6-2.3) and 2.3 (95% CI 1.2-4.4) for knees with inconsistent and consistent FKP, compared with those without FKP. This association was consistent across each level of pain severity on the Western Ontario and McMaster Universities Osteoarthritis Index.
Consistency of frequent knee pain is associated with an increased risk of TKR independently of knee pain severity.
Details
- Title: Subtitle
- Consistency of knee pain and risk of knee replacement: the Multicenter Osteoarthritis Study
- Creators
- Barton L Wise - Center for Healthy Aging, University of California, Davis School of Medicine, Sacramento, CA 95817, USA. barton.wise@ucdmc.ucdavis.eduDavid T FelsonMargaret ClancyJingbo NiuTuhina NeogiNancy E LaneJean HietpasJeffrey R CurtisLaurence A BradleyJames C TornerYuqing Zhang
- Resource Type
- Journal article
- Publication Details
- Journal of rheumatology, Vol.38(7), pp.1390-1395
- DOI
- 10.3899/jrheum.100743
- PMID
- 21498481
- PMCID
- PMC3222910
- NLM abbreviation
- J Rheumatol
- ISSN
- 0315-162X
- eISSN
- 1499-2752
- Publisher
- Canada
- Grant note
- U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS K12HD051958 / NICHD NIH HHS U01 AG18947 / NIA NIH HHS U01 AG18832 / NIA NIH HHS U01 AG019069 / NIA NIH HHS K12 HD051958 / NICHD NIH HHS U01 AG018820-11 / NIA NIH HHS U01 AG18820 / NIA NIH HHS P60 AR047785 / NIAMS NIH HHS K23 AR055127 / NIAMS NIH HHS K23 AR055127-04 / NIAMS NIH HHS U01 AG018820-10 / NIA NIH HHS U01 AG19069 / NIA NIH HHS U01 AG018820 / NIA NIH HHS
- Language
- English
- Date published
- 07/2011
- Academic Unit
- Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9983995016702771
Metrics
14 Record Views