Journal article
Consistency of observations from echograms made centrally in the Collaborative Ocular Melanoma Study COMS Report No. 13
Ophthalmic epidemiology, Vol.9(1), pp.11-27
02/2002
DOI: 10.1076/opep.9.1.11.1719
PMID: 11815892
Abstract
To describe the methods used by the Collaborative Ocular Melanoma Study (COMS) Echography Center for grading tumor echograms and to assess reliability of the grading system. Tumor echograms were graded at the COMS Echography Center using a specific protocol. To assess consistency, a five-percent random sample of all echographic gradings received as of June 30, 1996 was selected by the COMS Coordinating Center for re-evaluation at the COMS Echography Center. The results were compared with original data. Agreement between the two sets of gradings was evaluated by calculating overall percent agreement, and by using the kappa statistic for categorical features and intra-class correlation coefficients (ICC) for continuous measures. Overall agreement between original gradings and regradings was high. Agreement, based on the kappa statistic, between the original grading and the regrading was classified as 'moderate,' 'substantial,' or 'almost perfect' for nearly every variable graded. Kappas ranged from 0.47 for extrascleral extension to 0.82 for tumor shape. Intra-class correlation coefficients were 0.99 or higher for tumor height measurements and for the clock hour designation of the tumor apex. The only variable graded by the COMS Echography Center that did not have good agreement was 'confidence in tumor measurement.' The level of agreement (after adjusting for chance agreement) ranged from 'moderate' to 'almost perfect.' Grading for 'confidence of tumor measurement' differed between the original grading and the regrading but there was little difference in the tumor measurements. The COMS Echography Center has demonstrated that its grading protocol is consistent over time.
Details
- Title: Subtitle
- Consistency of observations from echograms made centrally in the Collaborative Ocular Melanoma Study COMS Report No. 13
- Creators
- Sandra Frazier Byrne - COMS Echography Center, Mars Hill, NC 28754, USAMarta J MarshH Culver BoldtRonald L GreenRobert N JohnsonDavid J WilsonCollaborat Ocular Melanoma Study G
- Resource Type
- Journal article
- Publication Details
- Ophthalmic epidemiology, Vol.9(1), pp.11-27
- Publisher
- England
- DOI
- 10.1076/opep.9.1.11.1719
- PMID
- 11815892
- ISSN
- 0928-6586
- eISSN
- 1744-5086
- Grant note
- EY06266 / NEI NIH HHS EY06257 / NEI NIH HHS EY06858 / NEI NIH HHS EY06280 / NEI NIH HHS EY06275 / NEI NIH HHS EY06899 / NEI NIH HHS EY06279 / NEI NIH HHS EY06288 / NEI NIH HHS EY06284 / NEI NIH HHS EY06258 / NEI NIH HHS EY06848 / NEI NIH HHS EY06276 / NEI NIH HHS EY06839 / NEI NIH HHS EY06844 / NEI NIH HHS EY06289 / NEI NIH HHS EY06253 / NEI NIH HHS EY06282 / NEI NIH HHS EY06268 / NEI NIH HHS EY06264 / NEI NIH HHS EY06291 / NEI NIH HHS EY06843 / NEI NIH HHS EY06260 / NEI NIH HHS EY06274 / NEI NIH HHS EY06283 / NEI NIH HHS EY06269 / NEI NIH HHS EY06265 / NEI NIH HHS EY06270 / NEI NIH HHS EY06287 / NEI NIH HHS EY06259 / NEI NIH HHS
- Language
- English
- Date published
- 02/2002
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9983980022002771
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