Journal article
Consortium for Dural Arteriovenous Fistula Outcomes Research (CONDOR): rationale, design, and initial characterization of patient cohort
Journal of neurosurgery, Vol.136(4), pp.951-961
09/10/2021
DOI: 10.3171/2021.1.JNS202790
PMID: 34507282
Abstract
Cranial dural arteriovenous fistulas (dAVFs) are rare lesions, hampering efforts to understand them and improve their care. To address this challenge, investigators with an established record of dAVF investigation formed an international, multicenter consortium aimed at better elucidating dAVF pathophysiology, imaging characteristics, natural history, and patient outcomes. This report describes the design of the Consortium for Dural Arteriovenous Fistula Outcomes Research (CONDOR) and includes characterization of the 1077-patient cohort.
Potential collaborators with established interest in the field were identified via systematic review of the literature. To ensure uniformity of data collection, a quality control process was instituted. Data were retrospectively obtained.
CONDOR comprises 14 centers in the United States, the United Kingdom, the Netherlands, and Japan that have pooled their data from 1077 dAVF patients seen between 1990 and 2017. The cohort includes 359 patients (33%) with Borden type I dAVFs, 175 (16%) with Borden type II fistulas, and 529 (49%) with Borden type III fistulas. Overall, 852 patients (79%) presented with fistula-related symptoms: 427 (40%) presented with nonaggressive symptoms such as tinnitus or orbital phenomena, 258 (24%) presented with intracranial hemorrhage, and 167 (16%) presented with nonhemorrhagic neurological deficits. A smaller proportion (224 patients, 21%), whose dAVFs were discovered incidentally, were asymptomatic. Many patients (85%, 911/1077) underwent treatment via endovascular embolization (55%, 587/1077), surgery (10%, 103/1077), radiosurgery (3%, 36/1077), or multimodal therapy (17%, 184/1077). The overall angiographic cure rate was 83% (758/911 treated), and treatment-related permanent neurological morbidity was 2% (27/1467 total procedures). The median time from diagnosis to follow-up was 380 days (IQR 120-1038.5 days).
With more than 1000 patients, the CONDOR registry represents the largest registry of cranial dAVF patient data in the world. These unique, well-annotated data will enable multiple future analyses to be performed to better understand dAVFs and their management.
Details
- Title: Subtitle
- Consortium for Dural Arteriovenous Fistula Outcomes Research (CONDOR): rationale, design, and initial characterization of patient cohort
- Creators
- Ridhima Guniganti - Washington University in St. Louis School of MedicineEnrico Giordan - Mayo ClinicChing-Jen Chen - University of Virginia Health SystemIsaac Josh Abecassis - University of WashingtonMichael R Levitt - University of WashingtonAndrew Durnford - University of SouthamptonJessica Smith - University of FloridaEdgar A Samaniego - University of IowaColin P Derdeyn - University of IowaAmanda Kwasnicki - University of Illinois ChicagoAli Alaraj - University of Illinois ChicagoAdriaan R E Potgieser - University Medical Center GroningenSamir Sur - University of MiamiStephanie H Chen - University of MiamiYoshiteru Tada - Tokushima UniversityEthan Winkler - University of California, San FranciscoRyan R L Phelps - University of California, San FranciscoPui Man Rosalind Lai - Brigham and Women's HospitalRose Du - Brigham and Women's HospitalAdib Abla - University of California, San FranciscoJunichiro Satomi - Tokushima UniversityRobert M Starke - University of MiamiJ Marc C van Dijk - University Medical Center GroningenSepideh Amin-Hanjani - University of Illinois ChicagoMinako Hayakawa - University of IowaBradley A Gross - University of PittsburghW Christopher Fox - University of FloridaDiederik Bulters - University of SouthamptonLouis J Kim - University of WashingtonJason Sheehan - University of Virginia Health SystemGiuseppe Lanzino - 5Radiology, Mayo Clinic, Rochester, MinnesotaJay F Piccirillo - 3Department of Otolaryngology, Washington University School of Medicine, St. Louis, MissouriAkash P Kansagra - 2Mallinckrodt Institute of Radiology, andGregory J Zipfel - Washington University in St. Louis School of MedicineConsortium for Dural Arteriovenous Fistula Outcomes Research
- Resource Type
- Journal article
- Publication Details
- Journal of neurosurgery, Vol.136(4), pp.951-961
- DOI
- 10.3171/2021.1.JNS202790
- PMID
- 34507282
- NLM abbreviation
- J Neurosurg
- eISSN
- 1933-0693
- Language
- English
- Date published
- 09/10/2021
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984230624202771
Metrics
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