Journal article
Construction of a Whole Body Blood Flow Model for Use in Positron Emission Tomography Imaging with [15O]Water
Journal of pharmacokinetics and biopharmaceutics, Vol.25(5), pp.539-568
10/1997
DOI: 10.1023/A:1025759213617
PMID: 9679222
Abstract
A whole body blood flow model (WBBFM) was developed and tested using STELLA II, an icon-driven mathematical simulation software package. The WBBFM uses parallel chambers to represent gray and white areas of the brain, body organs such as lungs, heart (right and left halves), injection site, and blood sampling sites. Input values to the WBBFM include organ blood flows, organ volumes, tissue:blood partition coefficients, injected activity, and data acquisition times for a positron emission tomography (PET) camera. Input variables included an injection function (e.g., bolus), and a blood flow function (e.g., transient variations in flow). The kinetic behavior of [
15
O]water, a freely diffusible radiotracer employed in PET to characterize blood flow was examined by the WBBFM. The physiologic behavior of water in the human body was emulated using the WBBFM and the model's predictive value was verified by comparing calculated results with the following properties of water: diffusibility, tissue:blood partition coefficient of [
15
O]water, and the mixing of [
15
O]water with total body water. The WBBFM simulated Kety's autoradiographic method used in the estimation of regional cerebral blood flow by PET using [
15
O]water. The application of the model to a cognitive activation study paradigm based on Kety's method is presented and its results compared to published literature data. With appropriate modification in the half-life, tissue:blood partition coefficient, and the amount of administered radioactivity, the WBBFM should prove useful us a tool to examine kinetics of other freely diffusible radiotracers used in PET.
Details
- Title: Subtitle
- Construction of a Whole Body Blood Flow Model for Use in Positron Emission Tomography Imaging with [15O]Water
- Creators
- Shalini Narayana - P.E.T. Imaging Center, 0911Z-JPP University of Iowa Hospitals and Clinics 200 Hawkins Drive Iowa City Iowa 52242Richard Hichwa - P.E.T. Imaging Center, 0911Z-JPP University of Iowa Hospitals and Clinics 200 Hawkins Drive Iowa City Iowa 52242Laura Ponto - P.E.T. Imaging Center, 0911Z-JPP University of Iowa Hospitals and Clinics 200 Hawkins Drive Iowa City Iowa 52242Richard Hurtig - Department of Speech Pathology and Audiology University of Iowa Iowa City IowaG. Leonard Watkins - P.E.T. Imaging Center, 0911Z-JPP University of Iowa Hospitals and Clinics 200 Hawkins Drive Iowa City Iowa 52242
- Resource Type
- Journal article
- Publication Details
- Journal of pharmacokinetics and biopharmaceutics, Vol.25(5), pp.539-568
- Publisher
- Kluwer Academic Publishers-Plenum Publishers; New York
- DOI
- 10.1023/A:1025759213617
- PMID
- 9679222
- ISSN
- 0090-466X
- eISSN
- 2168-5789
- Language
- English
- Date published
- 10/1997
- Academic Unit
- Radiology; Communication Sciences and Disorders; Research Administration; Pharmaceutical Sciences and Experimental Therapeutics; Physics and Astronomy; Radiation Oncology
- Record Identifier
- 9984051896402771
Metrics
15 Record Views