Consumption of a high n-3 polyunsaturated fatty acid diet during gradual mild physiological stress in rats

Km Appleton; Aj Grippo; Tg Beltz; Ak Johnson

doi:10.1016/j.plefa.2014.11.010

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Consumption of a high n-3 polyunsaturated fatty acid diet during gradual mild physiological stress in rats

Journal article

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Consumption of a high n-3 polyunsaturated fatty acid diet during gradual mild physiological stress in rats

Km Appleton, Aj Grippo, Tg Beltz and Ak Johnson

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), Vol.95, pp.11-18

04/01/2015

DOI: 10.1016/j.plefa.2014.11.010

PMCID: PMC4361260

PMID: 25534694

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Abstract

n-3 polyunsaturated fatty acids (n-3PUFAs) may be beneficial for anxiety and depression under stressful conditions. Studies however, typically utilise physical or sudden physiological stress, while gradual physiological stress is also relevant to human conditions. Using deoxycorticosterone acetate (DOCA) administration to induce gradual physiological stress, this study investigated the impact of n-3PUFAs under gradual physiological stress in rats. Animals (aged 2 months) (N=8–12/group) received daily injections of DOCA or vehicle and were concurrently fed a high n-3PUFA or control diet for eight weeks. Behavioural measures were taken throughout. Behavioural tests and physiological measures were conducted after six and eight weeks respectively. DOCA administration decreased plasma renin, plasma proteins and relative adrenal weight, and increased water intake, relative kidney weight, and anxiety in the open field. These findings demonstrate disruptions to the rennin-angiotensin-aldosterone system, a result of mild physiological stress, that also impact on anxiety behaviours. No effects of n-3PUFAs were found.

Clinical Biochemistry

Article

Cell Biology

Details

Title: Subtitle: Consumption of a high n-3 polyunsaturated fatty acid diet during gradual mild physiological stress in rats
Creators: Km Appleton
Aj Grippo
Tg Beltz
Ak Johnson
Resource Type: Journal article
Publication Details: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), Vol.95, pp.11-18
DOI: 10.1016/j.plefa.2014.11.010
PMID: 25534694
PMCID: PMC4361260
NLM abbreviation: Prostaglandins Leukot Essent Fatty Acids
ISSN: 0952-3278
eISSN: 1532-2823
Publisher: Elsevier BV
Grant note: name: the Queen׳s University of Belfast, Belfast; DOI: 10.13039/100000002, name: NIH, award: HL-14388, HL-98207, MH-80241
Language: English
Date published: 04/01/2015
Academic Unit: Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
Record Identifier: 9984002490802771

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